丘脑梗死患者海马结构和功能异常的MRI研究

发布时间：2018-08-18 14:34

【摘要】：目的探讨丘脑梗死后记忆功能减退患者海马的结构和功能改变情况,初步揭示其记忆功能减退的神经影像学机制。方法选取23例慢性丘脑梗死患者(TI组)和性别、年龄及受教育年限与之相匹配的健康志愿者28名(对照组),对所有受试者进行神经心理学评估、MRI全脑高分辨率解剖成像和静息态f MRI扫描。运用Freesuefer V.5.3软件进行海马分割及体积计算,采用DPARSF、SPM 8软件进行静息态f MRI数据预处理、ALFF值计算及统计分析。结果 (1)TI组MMSE评分(P=0.000)、词语短延迟回忆(P=0.001)、长延迟回忆(P=0.000)、再认(P=0.000)、复杂图形回忆(P=0.000)及数字倒背(P=0.006)分数均显著低于对照组;(2)TI组的病灶侧海马体积显著小于对照组(P=0.002),健侧海马体积与对照组比较无统计学差异(P=0.537);(3)与对照组比较,TI组患者的病灶侧海马ALFF值增加。结论丘脑梗死患者记忆功能减退可能是病灶侧海马体积萎缩所致,海马功能活动增强可能为代偿作用。
[Abstract]:Objective to investigate the changes of hippocampal structure and function in patients with memory impairment after thalamic infarction and to reveal the neuroimaging mechanism of memory impairment. Methods 23 patients with chronic thalamic infarction (TI group) and sex were selected. Twenty-eight healthy volunteers (control group) matched their ages and years of education were assessed by neuropsychological evaluation with high resolution anatomical imaging of the whole brain and rest f MRI scan. The hippocampal segmentation and volume calculation were carried out by Freesuefer V.5.3 software, and the rest f MRI data preprocessing and statistical analysis were performed by DPARSFSF-SPM8 software. Results (1) the scores of MMSE score (P0. 000), word short delay recall (P0. 001), long delay recall (P0. 000), recognition (P0. 000), complex pattern recall (P0. 000) and digital backside (P0. 006) in TI group were significantly lower than those in control group, (2) the hippocampal volume in TI group was significantly lower than that in control group (P0. 002), and the hippocampal volume in healthy side was significantly lower than that in control group (P0. 002). There was no significant difference in horse volume between the control group and the control group (P0. 537); (3). Compared with the control group, the hippocampal ALFF value of the TI group was higher than that of the control group. Conclusion the decrease of memory function in patients with thalamic infarction may be due to the atrophy of hippocampus, and the enhancement of hippocampal function may be a compensatory effect.
【作者单位】：川北医学院基础医学院解剖教研室;重庆医科大学附属第一医院放射科;
【基金】：国家临床重点专科建设项目经费资助(国卫办医函[2013]54号)
【分类号】：R743.3;R445.2

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