表观扩散系数鉴别诊断不同病理学特征的直肠腺癌
发布时间：2018-09-07 20:32
【摘要】：目的探讨ADC值鉴别不同病理学特征直肠腺癌的临床应用价值。方法回顾性分析48例经手术病理证实为直肠腺癌患者的MR资料,测量肿瘤组织的平均ADC值和最小ADC值,并比较不同术后病理学特征(肿瘤分化程度,T分期,T3期固有肌层外浸润深度,N分期,有无淋巴结外肿瘤种植,有无脉管癌栓、环周切缘是否受累)的差异;采用ROC曲线分析评价平均ADC值和最小ADC值对不同病理学特征直肠腺癌的鉴别诊断效能。结果直肠腺癌平均ADC值和最小ADC值在不同分化程度、T分期、T3期固有肌层外浸润深度和有无结外肿瘤种植差异均有统计学意义(P均0.05);最小ADC值在不同环周切缘状态间差异有统计学意义(P=0.035),平均ADC值差异无统计学意义(P=0.180);不同N分期和有无脉管癌栓平均ADC值和最小ADC值差异均无统计学意义(P均0.05)。平均ADC值和最小ADC值鉴别不同分化程度、T3分期、有无结外种植的直肠腺癌的ROC曲线下面积分别为0.92、0.82、0.79,0.86、0.81、0.74。结论平均ADC值、最小ADC值有助于鉴别不同病理学特征的直肠腺癌,可为术前直肠腺癌分期及评估预后提供更多的信息。
[Abstract]:Objective to evaluate the clinical value of ADC value in differentiating rectal adenocarcinoma with different pathological features. Methods the MR data of 48 patients with rectal adenocarcinoma proved by operation and pathology were analyzed retrospectively. The mean ADC value and minimum ADC value of tumor tissue were measured. The pathological characteristics of different postoperative patients were compared, such as the degree of differentiation of tumor and T stage, the depth of infiltration of the lamina propria muscularis in T3 stage, whether the tumor was implanted outside the lymph node, whether there was vascular tumor embolus or not, whether the circumferential margin was involved or not. ROC curve analysis was used to evaluate the differential diagnosis efficacy of mean ADC value and minimum ADC value for different pathological features of rectal adenocarcinoma. Results the mean ADC value and minimum ADC value of rectal adenocarcinoma were significantly different in the depth of extramuscular invasion and implantation of extratuberous tumor in T _ 3 stage of T _ 3 stage, and the minimum ADC value was at different circumferential incised margin (P < 0.05). There was significant difference between the two groups (P0. 035), but there was no significant difference in average ADC value (P0. 180), but there was no significant difference in mean ADC value and minimum ADC value in different N stages and with or without vascular tumor thrombus (P0. 05). The mean ADC value and the minimum ADC value were used to differentiate T 3 stage with or without extracolonic implantation. The area under the ROC curve of rectal adenocarcinoma with or without extracolonic implantation was 0.92 0.82 0. 790 卤0. 86 卤0. 81 卤0. 74 respectively. Conclusion the mean ADC value and minimum ADC value are helpful to distinguish rectal adenocarcinoma with different pathological features and provide more information for preoperative staging and prognosis evaluation of rectal adenocarcinoma.
【作者单位】： 复旦大学附属上海市第五人民医院放射科;
【基金】：上海市闵行区自然科学研究课题(2015MHZ052) 上海市第五人民医院科研课题(2011WYYJ05)
【分类号】：R735.37;R445.2
[Abstract]:Objective to evaluate the clinical value of ADC value in differentiating rectal adenocarcinoma with different pathological features. Methods the MR data of 48 patients with rectal adenocarcinoma proved by operation and pathology were analyzed retrospectively. The mean ADC value and minimum ADC value of tumor tissue were measured. The pathological characteristics of different postoperative patients were compared, such as the degree of differentiation of tumor and T stage, the depth of infiltration of the lamina propria muscularis in T3 stage, whether the tumor was implanted outside the lymph node, whether there was vascular tumor embolus or not, whether the circumferential margin was involved or not. ROC curve analysis was used to evaluate the differential diagnosis efficacy of mean ADC value and minimum ADC value for different pathological features of rectal adenocarcinoma. Results the mean ADC value and minimum ADC value of rectal adenocarcinoma were significantly different in the depth of extramuscular invasion and implantation of extratuberous tumor in T _ 3 stage of T _ 3 stage, and the minimum ADC value was at different circumferential incised margin (P < 0.05). There was significant difference between the two groups (P0. 035), but there was no significant difference in average ADC value (P0. 180), but there was no significant difference in mean ADC value and minimum ADC value in different N stages and with or without vascular tumor thrombus (P0. 05). The mean ADC value and the minimum ADC value were used to differentiate T 3 stage with or without extracolonic implantation. The area under the ROC curve of rectal adenocarcinoma with or without extracolonic implantation was 0.92 0.82 0. 790 卤0. 86 卤0. 81 卤0. 74 respectively. Conclusion the mean ADC value and minimum ADC value are helpful to distinguish rectal adenocarcinoma with different pathological features and provide more information for preoperative staging and prognosis evaluation of rectal adenocarcinoma.
【作者单位】： 复旦大学附属上海市第五人民医院放射科;
【基金】：上海市闵行区自然科学研究课题(2015MHZ052) 上海市第五人民医院科研课题(2011WYYJ05)
【分类号】：R735.37;R445.2
【参考文献】
相关期刊论文 前2条
1 张文娟;蒋健;叶建军;刘光耀;马强华;;扩散加权成像ADC值与直肠癌预后因素的相关性研究[J];中国医学影像技术;2013年10期
2 陈应明;庄晓f，
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