双指数扩散加权成像参数与鼻咽癌临床分期的关系

发布时间：2018-09-09 14:54

【摘要】：目的:探讨双指数模型(IVIM)扩散加权成像参数与鼻咽癌(NPC)临床分期的相关性,评价其在评估NPC侵袭和转移方面的价值。方法:对49例NPC初治患者行IVIM扩散加权成像和临床分期(中国2008分期),分析IVIM各参数(ADCstand、ADCslow、ADCfast、Ffast)与临床分期之间的相关性。结果:T分期与ADCslow值呈负相关(r=-0.356,P=0.012),与ADCfast值呈正相关(r=0.388,P=0.006);ADCstand值与总分期(r=0.410,P=0.003)、N分期(r=0.313,P=0.029)、M分期(r=0.349,P=0.014)均呈正相关;ADCstand值在不同总分期、N分期及M分期之间存在显著差异(P0.05);ADCslow值在不同总分期、T分期及N分期之间亦存在显著差异(P0.05)。结论:NPC的总分期、T分期、N分期和M分期与多个IVIM参数之间存在相关性。IVIM参数有可能作为无创性反映NPC组织特性、侵袭性及疾病进展程度的影像学生物标志,为临床治疗方案的设计提供参考依据。
[Abstract]:Objective: to investigate the correlation between (IVIM) diffusion-weighted imaging parameters and clinical staging of nasopharyngeal carcinoma (NPC) (NPC), and to evaluate its value in evaluating the invasion and metastasis of nasopharyngeal carcinoma (NPC). Methods: IVIM diffusion-weighted imaging and clinical staging (2008 stages in China) were performed in 49 patients with NPC. The correlation between IVIM parameters (ADCstand,ADCslow,ADCfast,Ffast) and clinical staging was analyzed. Results there was a negative correlation between ADCslow and ADCslow (r-0.356P0.012) and a positive correlation with ADCfast (r 0.388P0. 006). (P 0.05) there was significant difference between ADCstand and M stage (r 0.313P 0.029) and M stage (r0.349P0.014) (P 0.05). There were also significant differences between stages and N stages (P0.05). Conclusion the correlation between IVIM parameters and T / N staging and M staging in the total staging and T staging of NPC may be used as a noninvasive imaging biomarker to reflect the tissue characteristics, invasiveness and the degree of disease progression of NPC. To provide reference for the design of clinical treatment plan.
【作者单位】：中南大学湘雅医学院附属肿瘤医院;
【基金】：湖南省科技厅资助课题(2010FJ3097) 中南大学湘雅医学院附属肿瘤医院资助课题(A2012-01)
【分类号】：R739.63;R445.2

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