扩散加权成像信号与液体内蛋白质的相关性实验研究
发布时间：2018-09-13 14:50
【摘要】：目的蛋白质是影响扩散加权成像(DWI)信号及表观扩散系数(ADC)值的主要因素,使囊液于DWI上呈高信号,ADC值降低,但在实际工作中并非完全如此,本研究拟深入了解蛋白质的类型、浓度对其的影响。材料与方法通过在体外制作不同浓度的白蛋白溶液、球蛋白溶液及同浓度不同比例的白蛋白和球蛋白混合溶液体模,采用GE 1.5T超导型MRI成像系统,定量研究其对DWI信号和ADC值的影响。结果 1 ADC值与白蛋白及球蛋白溶液浓度呈线性负相关(37℃时,r白=-0.849,P白0.05;r球=-0.843,P球0.05;40℃时,r白=-0.894,P白0.05;r球=-0.819,P球0.05);DWI信号强度与白蛋白溶液的浓度呈线性正相关(37℃时,r=0.753,P0.05;40℃时,r=0.845,P0.05),而与球蛋白溶液的浓度无相关性(37℃时,r=-0.222,P0.05;40℃,r=-0.270,P0.05)。2相同浓度和温度下,白蛋白溶液DWI信号强度高于球蛋白溶液(t=3.96,P0.001),ADC值差异无统计学意义(t=0.61,P0.05)。结论通过对囊液DWI及ADC值的定量分析,可以初步了解囊液的性质,从而为体内囊性病变的定性诊断提供理论依据。
[Abstract]:Objective protein is the main factor that affects diffusion weighted imaging (DWI) signal and apparent diffusion coefficient (ADC), which reduces the (ADC) value of cystic fluid on DWI, but it is not exactly the case in practice. The effect of concentration on it. Materials and methods GE 1.5T superconducting MRI imaging system was used to fabricate different concentrations of albumin solution, globulin solution and mixed solution of albumin and globulin in vitro. The effect on DWI signal and ADC value was studied quantitatively. Results 1 there was a linear negative correlation between the ADC value and the concentration of albumin and globulin solution. The signal intensity of Albumin and globulin solution was positively correlated with the concentration of albumin solution at 37 鈩，
本文编号：2241486
[Abstract]:Objective protein is the main factor that affects diffusion weighted imaging (DWI) signal and apparent diffusion coefficient (ADC), which reduces the (ADC) value of cystic fluid on DWI, but it is not exactly the case in practice. The effect of concentration on it. Materials and methods GE 1.5T superconducting MRI imaging system was used to fabricate different concentrations of albumin solution, globulin solution and mixed solution of albumin and globulin in vitro. The effect on DWI signal and ADC value was studied quantitatively. Results 1 there was a linear negative correlation between the ADC value and the concentration of albumin and globulin solution. The signal intensity of Albumin and globulin solution was positively correlated with the concentration of albumin solution at 37 鈩，
本文编号：2241486
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