高频超声评价表阿霉素复合药物对乳腺癌患者血管内皮功能的影响

发布时间：2018-10-09 08:17

【摘要】：目的采用高频超声评估表阿霉素(Epi)复合药物对乳腺癌患者血管内皮功能的影响。方法收集140例乳腺癌术后患者,分为3组:A组为对照组,40例,未给予化疗。B组50例,采用以Epi为主化疗方案(环磷酰胺+Epi+5-氟尿嘧啶),Epi累积剂量180~240mg/m2;C组50例,化疗方案与B组相同,Epi≥360mg/m2。对3组患者静息状态、反应性充血(内皮依赖性)及含服硝酸甘油后内皮功能(内皮非依赖性)进行检测,比较内皮依赖性及内皮非依赖性肱动脉内径变化。结果 1A组与B组肱动脉内皮依赖性舒张功能(EDD)的差异无统计学意义[(8.05±1.89)%vs(7.48±2.06)%,P0.05],C组EDD[(6.49±1.63)%]明显减低,与A组、B组的差异均有统计学意义(P均0.05);2与A组[(14.81±4.20)%]比较,B组[(14.31±3.89)%]、C组内皮非依赖性舒张功能[NEDD,(13.31±3.45)%]均减低,但3组间差异无统计学意义(P0.05);3EDD、NEDD与静息状态下肱动脉基础内径(D0)无相关性(r=-0.02,0.01,P均0.05),EDD、NEDD与反应性充血后肱动脉内径(D1)呈正相关(r=0.43,0.17,P0.05),与含服硝酸甘油后肱动脉内径(D2)呈正相关(r=0.23,0.69,P0.05)。结论较大剂量Epi复合药物可致乳腺癌患者EDD功能受损,但其NEDD功能未见明显受损。
[Abstract]:Objective to evaluate the effect of epirubicin (Epi) on vascular endothelial function in breast cancer patients by high frequency ultrasound. Methods one hundred and forty patients with breast cancer after operation were divided into 3 groups: control group (n = 40) and group B (n = 50). 50 patients in group C were treated with Epi regimen (cyclophosphamide Epi 5-fluorouracil). The chemotherapy regimen was the same as that in group B with Epi 鈮，

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