3.0 TMRI表观扩散系数诊断中度肝纤维化价值的实验研究

发布时间：2018-10-21 17:13

【摘要】：目的探讨3.0 T MRI表观扩散系数(ADC)诊断中度肝纤维化的价值。方法采用猪血清腹腔注射复制肝纤维化大鼠模型。采用3.0 T MRI行DWI检查,计算b值=800 s/mm~2时ADC值。DWI检查后快速处死大鼠,行病理检查,对照组(12只)、轻度肝纤维化组(S_1期18只)和中度肝纤维化组(S_2、S_3期共22只)比较采用单因素方差分析及SNK法多重比较。采用ROC曲线分析ADC值区分中度和轻度肝纤维化的效能。结果中度肝纤维化组大鼠肝脏ADC值为(1.47±0.39)×10~(-3)mm~2/s,轻度肝纤维化组大鼠肝脏ADC值为(1.78±0.67)×10~(-3)mm~2/s,两组比较,差异有统计学意义,对照组与轻度肝纤维化组大鼠肝脏ADC值比较差异无统计学意义(P0.05),与中度组比较差异有统计学意义(P0.05)。ADC值区分中度肝纤维化和轻度肝纤维化的ROC曲线下面积(AUC)为0.79,以ADC值=1.68×10~(-3)mm~2/s为界值时,诊断的敏感性和特异性分别为61%和100%。结论 3.0 T MRI功能弥散加权成像能反映早期肝纤维化微观改变,肝脏ADC值有助于中度肝纤维化的诊断。
[Abstract]:Objective to evaluate the value of 3. 0 T MRI apparent diffusion coefficient (ADC) in the diagnosis of moderate hepatic fibrosis. Methods the rat model of hepatic fibrosis was induced by intraperitoneal injection of pig serum. DWI was performed with 3.0T MRI, and the ADC value of b = 800s / mm-2 was calculated. The rats were killed quickly after DWI examination, and pathological examination was performed. Control group (n = 12), mild hepatic fibrosis group (n = 18) and moderate hepatic fibrosis group (n = 22) were compared by univariate ANOVA and SNK method. ROC curve was used to analyze the efficacy of ADC value in differentiating moderate and mild hepatic fibrosis. Results the liver ADC value of moderate hepatic fibrosis group was (1.47 卤0.39) 脳 10 ~ (-3) mm~2/s, and the liver ADC value of mild hepatic fibrosis group was (1.78 卤0.67) 脳 10 ~ (-3) mm~2/s,. There was no significant difference in ADC between the control group and the mild hepatic fibrosis group (P0.05), but there was a significant difference between the control group and the moderate group (P0.05). ADC). The area under the ROC curve was 0.79. When ADC = 1. 68 脳 10 ~ (-3) mm~2/s is the bound value, The sensitivity and specificity of diagnosis were 61% and 100%, respectively. Conclusion 3.0T MRI diffusion-weighted imaging can reflect the microscopic changes of early hepatic fibrosis, and the ADC value of liver is helpful for the diagnosis of moderate hepatic fibrosis.
【作者单位】：吉林油田总医院;中南大学湘雅医学院附属海口医院;海南医学院附属医院;
【基金】：海南省自然科学基金(No:817390)
【分类号】：R445.2;R575.2

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