超声评价川崎病患儿肱动脉血管内皮功能障碍

发布时间：2018-10-29 23:09

【摘要】：目的采用血流介导的血管扩张(FMD)分析川崎病(KD)患儿各期肱动脉内皮功能。方法测定50例KD患儿(KD组,亚急性期3人失访、恢复期2人失访)、28例发热待查患儿(发热对照组)及19名正常对照儿童(健康对照组)肱动脉FMD,并对恢复期患儿依据冠状动脉有无损害分为两个亚组,对各组FMD进行统计学分析。结果 KD组急性期、亚急性期、恢复期、发热对照组和健康对照组FMD差异有统计学意义(χ2=54.242,P0.001);KD组急性期、亚急性期、恢复期分别与发热对照组和健康对照组两两比较,差异均有统计学意义(P均0.001);恢复期KD患儿有无冠状动脉扩张性损害FMD差异无统计学意义(P=0.421)。结论 KD患儿急性期、亚急性期和恢复期均存在血管内皮功能障碍;肱动脉FMD可反映KD患儿血管内皮功能障碍,可为KD患儿诊疗监测提供有用信息。
[Abstract]:Objective to analyze the endothelial function of brachial artery in children with Kawasaki disease (Kawasaki disease) (KD) by blood flow mediated vasodilation (FMD). Methods FMD, of brachial artery was measured in 50 children with KD (KD group, 3 patients in subacute phase, 2 patients in convalescent period), 28 children with fever (fever control group) and 19 normal children (healthy control group). The convalescent children were divided into two subgroups according to coronary artery injury. The FMD of each group was analyzed statistically. Results there were significant differences in FMD between KD group, subacute stage, convalescence stage, febrile control group and healthy control group (蠂 2, 54.242, P 0.001). There were significant differences in acute, subacute and recovery stages between KD group and febrile control group and healthy control group (P 0.001). There was no significant difference in FMD in convalescent KD patients with or without dilated coronary artery damage (P0. 421). Conclusion there are vascular endothelial dysfunction in children with KD in acute, subacute and convalescent stages, and FMD of brachial artery can reflect vascular endothelial dysfunction in children with KD and provide useful information for diagnosis and treatment of KD.
【作者单位】：江苏省沭阳人民医院功能检查科;苏州大学附属儿童医院放射科;苏州大学附属儿童医院心脏超声室;
【基金】：江苏省苏州市科技局计划项目(SYS201355)
【分类号】：R725.4;R445.1

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