脊髓受累型多发性硬化患者静息态功能磁共振的局部一致性研究
发布时间：2018-10-30 09:20
【摘要】：目的应用静息态功能磁共振(RS-f MRI)局部一致性(Re Ho)技术,探讨仅有脊髓受累型多发性硬化患者(MS-SSCI)血氧水平依赖信号的Re Ho。方法对23例MS-SSCI患者(MS-SSCI组)及23名年龄、性别相匹配的健康志愿者(对照组)进行RS-f MRI扫描,比较两组间Re Ho改变的脑区,进一步分析MS-SSCI患者Re Ho值与临床扩展残疾状态量表(EDSS)评分及病程间的相关性。结果与对照组相比,MS-SSCI患者左侧小脑脚Ⅱ、双侧颞中回、左侧纺锤体、左侧中央前回、右侧辅助运动区的Re Ho明显降低;左侧小脑Ⅸ区、双侧尾状核、左侧后扣带回的Re Ho明显升高(双样本t检验,经Alpha Sim校正,P0.01,体素大小40)。相关性分析结果显示,MS-SSCI患者左侧后扣带回Re Ho值和EDSS呈正相关(r=0.586,P=0.003)。结论 MS-SSCI患者静息状态下存在局部脑功能异常,且功能异常与临床残疾状况密切相关,RS-f MRI在探测MS-SSCI脑内潜在性病变方面具有重要价值。
[Abstract]:Objective to investigate the application of resting functional magnetic resonance (RS-f MRI) locally consistent (Re Ho) technique in the study of Re Ho. with only oxygen-dependent signal in patients with multiple sclerosis (MS-SSCI) with spinal cord involvement. Methods RS-f MRI scans were performed in 23 MS-SSCI patients (MS-SSCI group) and 23 age-matched healthy volunteers (control group). The brain regions of Re Ho were compared between the two groups. To further analyze the correlation between Re Ho value of MS-SSCI patients and (EDSS) score of clinical extended disability status scale and course of disease. Results compared with the control group, the Re Ho of left cerebellum 鈪，
本文编号：2299595
[Abstract]:Objective to investigate the application of resting functional magnetic resonance (RS-f MRI) locally consistent (Re Ho) technique in the study of Re Ho. with only oxygen-dependent signal in patients with multiple sclerosis (MS-SSCI) with spinal cord involvement. Methods RS-f MRI scans were performed in 23 MS-SSCI patients (MS-SSCI group) and 23 age-matched healthy volunteers (control group). The brain regions of Re Ho were compared between the two groups. To further analyze the correlation between Re Ho value of MS-SSCI patients and (EDSS) score of clinical extended disability status scale and course of disease. Results compared with the control group, the Re Ho of left cerebellum 鈪，
本文编号：2299595
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