磁共振扩散张量成像在评价儿童脑内部分皮质脊髓束发育中的应用

发布时间：2018-11-19 21:30

【摘要】：目的应用磁共振扩散成像技术探讨儿童皮质脊髓束年龄和性别差异及其变化规律。方法 90例无中枢神经系统症状及体征且颅脑磁共振检查正常的儿童(年龄5d~18岁)。按年龄分为5组:婴儿组(组1,≤1岁),幼儿组(组2,1~3岁),学龄前组(组3,3~6岁),学龄组(组4,6~12岁),青春发育期组(组5,12~18岁)。每个年龄组内再按性别分为男、女2组。各组儿童分别行头部扩散张量成像,根据感兴趣法选取皮质脊髓束感兴趣区并重建,测量重建的皮质脊髓束的扩散张量参数并进行统计学分析。结果各年龄组的表观扩散系数(ADC)值、分数各向异性(FA)值、纤维示踪平均长度、体积以及示踪的纤维束数量不完全相同(P0.01);组间的两两比较间发现,1组与2组间ADC值、FA值及示踪纤维平均长度差异具有统计学意义;2组与3组间FA值差异具有统计学意义;3组与4组间ADC值、FA值、示踪纤维平均长度、纤维束数目及体积差异均具有统计学意义。ADC值与年龄间呈负相关,余参数与年龄间呈正相关。结论儿童皮质脊髓束发育具有阶段性,且具有阶段性特征;磁共振扩散张量技术可用于观测儿童皮质脊髓束,评价其发育状况。
[Abstract]:Objective to investigate the age and sex differences of corticospinal tract in children by using magnetic resonance diffusion imaging (MRI). Methods 90 children (aged 5d~18) with no symptoms and signs of central nervous system and normal craniocerebral magnetic resonance examination were studied. They were divided into five groups according to their age: infant group (group 1, 鈮，

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