纵向分层应变技术评估蒽环类药物化疗后乳腺癌患者左心收缩功能

发布时间：2018-12-09 08:23

【摘要】：目的应用二维分层应变技术评估蒽环类药物化疗后乳腺癌患者早期左心室收缩功能的变化。方法收集接受蒽环类药物化疗的乳腺癌患者32例及未接受化疗的乳腺癌术后患者20例。化疗患者于化疗3个月、5个月后接受常规超声心动图采集图像,应用EchoPAC软件测量左心室长轴各切面收缩期心内膜下、中层和心外膜下心肌的整体纵向应变(GLS)及各节段(基底段、中间段、心尖段)的纵向应变。结果与对照组比较,随着化疗周期的增加,蒽环类药物化疗后乳腺癌患者心内膜下、中层和心外膜下心肌GLS均减低(P均0.05),而左心室射血分数(LVEF)无显著差异(P0.05);与对照组比较,除各层心肌心尖段外,化疗后患者各层心肌基底段、中间段纵向应变减低(P均0.05)。结论纵向分层应变技术可准确评估乳腺癌蒽环类药物化疗后左心各层心肌整体及局部收缩功能,为判断心肌损伤程度提供了新的方法。
[Abstract]:Objective to evaluate the changes of left ventricular systolic function in patients with breast cancer after anthracycline chemotherapy by two dimensional stratified strain technique. Methods 32 breast cancer patients receiving anthracycline chemotherapy and 20 breast cancer patients without chemotherapy were collected. After 3 months of chemotherapy and 5 months after chemotherapy, the patients received conventional echocardiography to collect images, and EchoPAC software was used to measure the subsystolic endocardium on the long axis of left ventricle. The overall longitudinal strain (GLS) of the middle and epicardial myocardium and the longitudinal strain of each segment (basal segment, middle segment, apical segment). Results compared with the control group, with the increase of chemotherapy cycle, the GLS of subendocardial, middle and epicardial myocardium in patients with breast cancer decreased after anthracycline chemotherapy (P0. 05). There was no significant difference in left ventricular ejection fraction (LVEF) (P0.05). Compared with the control group, the longitudinal strain in the basal and middle segments of the myocardium decreased after chemotherapy except the apical segment of the myocardium (all P 0.05). Conclusion Longitudinal stratification strain technique can accurately evaluate the global and local contractile function of left ventricular myocardium after anthracycline chemotherapy in breast cancer. It provides a new method for judging the degree of myocardial injury.
【作者单位】：江苏大学医学院基础医学系;
【分类号】：R540.45;R737.9

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