心脏MRI评估肺动脉高压患者左、右心功能的研究
发布时间：2018-12-09 19:37
【摘要】：目的：探讨心脏MRI评估肺动脉高压患者左、右心室功能的临床应用价值。 材料与方法：对30例肺动脉高压患者及30例健康志愿者(对照组)进行心脏MRI检查,分别计算两组左、右心功能及左、右室心肌质量,心室质量指数(VMI)为舒张末期RV MM与LV MM的比值。肺动脉高压组根据病情进展分为慢性阻塞性肺病组和肺心病组。两组比较采用t检验,多组比较采用单因素方差分析,两两比较采用LSD-t检验。 结果：5例肺动脉高压患者MRI检查时由于屏气时间长、不能配合而排除,与对照组比较,PH组患者RV EDV、ESV、MM均显著高于对照组(P0.05), RV EF、SV显著低于对照组(P0.05)。PH组患者LV EDV、SV、EF、PER、PFR显著低于对照组(P0.05),而LV ESV、MM与对照组的差异均无统计学意义(P0.05)。PH组VMI显著高于对照组(P0.05)。与对照组比较COPD组、CP组患者RV EDV、ESV、MM均显著高于对照组(P0.05), RV EF、SV显著低于对照组(P0.05)。与对照组比较,COPD组患者LV SV、PFR显著低于对照组(P0.05),而LV EDV、ESV、EF、PER和MM与对照组的差异均无统计学意义(P0.05)。与对照组比较,CP组患者LV EDV、SV、EF、PER和PFR显著低于对照组(P0.05),而LV ESV和MM与对照组的差异均无统计学意义(P0.05)。 结论：肺动脉高压导致右心室扩大,右心功能下降,同时左心功能受损,且左心舒张功能受损早于收缩功能受损。心脏MRI能够无创、准确的提供PH患者RV与LV的功能信息,对于评价PH患者心室功能具有重要价值。
[Abstract]:Objective: to evaluate the clinical value of cardiac MRI in assessing left and right ventricular function in patients with pulmonary hypertension. Materials and methods: heart MRI was performed in 30 patients with pulmonary hypertension and 30 healthy volunteers (control group). The left and right cardiac function and the myocardial mass of left and right ventricle were calculated respectively in the two groups. The ventricular mass index (VMI) was the ratio of end-diastolic RV MM to LV MM. Pulmonary hypertension group was divided into chronic obstructive pulmonary disease group and cor pulmonale group. T test was used in two groups, single factor analysis of variance and LSD-t test were used in multiple groups. Results: in 5 patients with pulmonary hypertension, the RV EDV,ESV,MM in PH group was significantly higher than that in control group (P0.05), RV EF,) because of the long breath holding time and could not be combined with RV EDV,ESV,MM examination in 5 patients with pulmonary hypertension. SV was significantly lower than that in control group (P0.05) LV EDV,SV,EF,PER,PFR in). PH group was significantly lower than that in control group (P0.05), while LV ESV, was significantly lower in). PH group. There was no significant difference between MM and control group (P0.05 VMI in). PH group was significantly higher than that in control group (P0.05). Compared with control group, RV EDV,ESV,MM in CP group was significantly higher than that in control group (P0.05), RV EF,SV was significantly lower than that in control group (P0.05). Compared with the control group, the LV SV,PFR of COPD group was significantly lower than that of the control group (P0.05), while the LV EDV,ESV,EF,PER and MM had no significant difference with the control group (P0.05). Compared with control group, LV EDV,SV,EF,PER and PFR in CP group were significantly lower than those in control group (P0.05), while LV ESV and MM had no statistical significance (P0.05). Conclusion: pulmonary hypertension leads to right ventricular dilatation, decreased right ventricular function, and impaired left ventricular function, and the left ventricular diastolic function is impaired earlier than that of systolic function. Cardiac MRI can provide noninvasive and accurate information about RV and LV in patients with PH. It has important value in evaluating ventricular function in PH patients.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2;R544.1
本文编号：2369922
[Abstract]:Objective: to evaluate the clinical value of cardiac MRI in assessing left and right ventricular function in patients with pulmonary hypertension. Materials and methods: heart MRI was performed in 30 patients with pulmonary hypertension and 30 healthy volunteers (control group). The left and right cardiac function and the myocardial mass of left and right ventricle were calculated respectively in the two groups. The ventricular mass index (VMI) was the ratio of end-diastolic RV MM to LV MM. Pulmonary hypertension group was divided into chronic obstructive pulmonary disease group and cor pulmonale group. T test was used in two groups, single factor analysis of variance and LSD-t test were used in multiple groups. Results: in 5 patients with pulmonary hypertension, the RV EDV,ESV,MM in PH group was significantly higher than that in control group (P0.05), RV EF,) because of the long breath holding time and could not be combined with RV EDV,ESV,MM examination in 5 patients with pulmonary hypertension. SV was significantly lower than that in control group (P0.05) LV EDV,SV,EF,PER,PFR in). PH group was significantly lower than that in control group (P0.05), while LV ESV, was significantly lower in). PH group. There was no significant difference between MM and control group (P0.05 VMI in). PH group was significantly higher than that in control group (P0.05). Compared with control group, RV EDV,ESV,MM in CP group was significantly higher than that in control group (P0.05), RV EF,SV was significantly lower than that in control group (P0.05). Compared with the control group, the LV SV,PFR of COPD group was significantly lower than that of the control group (P0.05), while the LV EDV,ESV,EF,PER and MM had no significant difference with the control group (P0.05). Compared with control group, LV EDV,SV,EF,PER and PFR in CP group were significantly lower than those in control group (P0.05), while LV ESV and MM had no statistical significance (P0.05). Conclusion: pulmonary hypertension leads to right ventricular dilatation, decreased right ventricular function, and impaired left ventricular function, and the left ventricular diastolic function is impaired earlier than that of systolic function. Cardiac MRI can provide noninvasive and accurate information about RV and LV in patients with PH. It has important value in evaluating ventricular function in PH patients.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2;R544.1
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