超声心动图评价肺动脉高压大鼠右心结构和功能的动态变化

发布时间：2018-12-16 05:50

【摘要】：目的通过超声心动图无创性定量评价肺动脉高压大鼠右心结构和功能的变化,探讨早期评价右心功能的指标。方法选取SD大鼠40只,随机分为5组,每组8只,分别标记为对照组和实验组(3周、4周、5周、6周亚组),对实验组大鼠腹部皮下注射野百合碱,分别于给药后3周、4周、5周、6周进行超声心动图检查,再进行右心导管测压。采用ECHOPAC工作站脱机分析,测量超声心动图数据,比较各组数据的差异。结果实验组较对照组肺动脉压力升高,差异有统计学意义(P均0.05)。4周亚组右心室中间段内径、右心室面积变化率、右心室侧壁厚度、偏心指数、肺动脉瓣加速时间与射血时间比值以及5周亚组三尖瓣瓣环位移、右心房横径、右心房长径、右心房面积与对照组相比,差异有统计学意义(P均0.05)。结论右心室中间段内径、右心室面积变化率、右心室侧壁厚度,偏心指数、肺动脉瓣加速时间与射血时间比值能较早反映大鼠肺动脉压力升高时右心室结构及功能的改变。
[Abstract]:Objective to evaluate the changes of the structure and function of right heart in rats with pulmonary hypertension by echocardiography. Methods Forty SD rats were randomly divided into 5 groups, 8 rats in each group, marked as control group and experimental group (3 weeks, 4 weeks, 5 weeks, 6 weeks subgroups) respectively. The experimental group rats were subcutaneously injected with monocrotaline 3 weeks after administration of monocrotaline. Echocardiography was performed at 4 weeks, 5 weeks and 6 weeks, and then right cardiac catheterization was performed. The data of echocardiography were measured by ECHOPAC workstation off-line analysis, and the differences of each group were compared. Results the pulmonary artery pressure in the experimental group was significantly higher than that in the control group (P 0.05). In the 4-week subgroup, the diameter of the middle segment of the right ventricle, the area change rate of the right ventricle, the thickness of the lateral wall of the right ventricle, the eccentricity index of the right ventricle were increased. The ratio of pulmonary valve acceleration time to ejection time and tricuspid annular displacement, right atrial transverse diameter, right atrial long diameter and right atrial area in the 5-week subgroup were significantly different from those in the control group (P 0.05). Conclusion the diameter of middle segment of right ventricle, the change rate of area of right ventricle, the thickness of lateral wall of right ventricle, the eccentric index, the ratio of acceleration time of pulmonary valve to ejection time can reflect the changes of structure and function of right ventricle in rats with elevated pulmonary artery pressure earlier.
【作者单位】：中国医科大学附属第一医院心血管超声科;中国医科大学附属第一医院老年医学科;
【基金】：高等学校博士学科点专项科研基金(20112104110010)
【分类号】：R540.45;R544.1

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