超声心动图在构建舒张性心力衰竭模型兔过程中的应用价值

发布时间：2019-01-01 11:57

【摘要】：背景:相关医学研究表明,与收缩性心力衰竭相比,单纯性舒张性心力衰竭的发病率更高。目的:探讨超声心动图在兔单纯性舒张性心力衰竭动物模型监测中的应用价值。方法:选取60只健康新西兰雄性兔,运用腹主动脉缩窄法建立压力负荷性心肌肥厚模型兔,并设假手术组作对照,对各组兔进行超声心动图监测和左心导管检查,对其左室舒张末压和松弛时间常数进行测定,以对单纯性舒张性心力衰竭的存在情况进行有效判断。结果与结论:与假手术组相比,压力负荷性心肌肥厚模型兔建模前、建模后1,4,8周的主动脉瓣环径均明显变短(P0.05);建模后8周模型兔心房收缩期逆向血流最大流速降低(P0.05);建模后8周的左室干质量,左室干质量与体质量的比值、左室后壁厚度、收缩压、室间隔、左室收缩压和左室舒张末压水平均明显增高(P0.05)。结果证实,实验成功建立了单纯性舒张性心力衰竭模型兔,超声心动图可有效监测心肌肥厚时的左室收缩和舒张功能。
[Abstract]:Background: medical studies have shown that the incidence of simple diastolic heart failure is higher than that of systolic heart failure. Objective: to investigate the value of echocardiography in monitoring simple diastolic heart failure in rabbits. Methods: 60 healthy New Zealand male rabbits were used to establish the pressure overload myocardial hypertrophy model rabbits by abdominal aortic coarctation. The sham operation group was used as control group. Echocardiographic monitoring and left cardiac catheterization were performed in each group. The left ventricular end-diastolic pressure and relaxation time constant were measured to determine the presence of simple diastolic heart failure. Results and conclusion: compared with the sham operation group, the aortic annular diameter of the model rabbits with myocardial hypertrophy induced by pressure load was significantly shorter at the 1st and 8th week after modeling (P0.05). At 8 weeks after modeling, the maximum flow velocity of reverse atrial systolic blood flow in rabbits was decreased (P0.05). The left ventricular dry mass, the ratio of left ventricular trunk mass to body mass, left ventricular posterior wall thickness, systolic pressure, interventricular septum, left ventricular systolic pressure and left ventricular end-diastolic pressure were significantly increased 8 weeks after modeling (P0.05). The results showed that the rabbit model of simple diastolic heart failure was successfully established and echocardiography could effectively monitor the left ventricular systolic and diastolic function during myocardial hypertrophy.
【作者单位】：解放军南京军区福州总医院第一附属医院;
【分类号】：R540.45;R541.6;R-332

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