超声造影观察颈动脉斑块易损性的研究

发布时间：2018-12-31 12:18

【摘要】：目的探讨超声造影评估颈动脉粥样硬化斑块易损性的可行性。资料与方法选取经颈动脉超声检查发现动脉粥样硬化斑块的34例患者,均行超声造影检查,观察斑块内有无造影剂增强及增强特征,应用时间-信号强度曲线计算斑块峰值强度(PI)、达峰时间(TTP)、增强密度(DE)。结果软斑组及混合斑组造影剂增强比率分别为100.0%(18/18)、85.7%(12/14),差异无统计学意义(χ2=0.847,P0.05)。肩部、基底部、尾部增强斑块分别为70.0%、23.3%、6.7%,差异有统计学意义(χ2=29.100,P0.001),增强斑块在各部位分布比率从高到低依次为肩部基底部尾部。增强斑块与部位顺序呈正相关(r=0.404,P0.01)。软斑组与混合斑组的TTP比较,差异无统计学意义(t=0.479,P0.05)。软斑组及混合斑组的PI及DE比较,差异有统计学意义(t=7.497、12.224,P0.05)。结论超声造影能够显示颈部动脉粥样硬化斑块内的新生血管,有助于斑块易损性的评估。
[Abstract]:Objective to evaluate the feasibility of contrast-enhanced ultrasonography in assessing the vulnerability of carotid atherosclerotic plaques. Materials and methods Thirty-four patients with atherosclerotic plaques found by transcarotid ultrasound were examined by contrast-enhanced ultrasonography. Calculation of patch peak intensity (PI), peak time (TTP), enhancement density (DE). Using time-signal intensity curve Results the contrast enhancement rates of soft spot group and mixed plaque group were 100.0% (18 / 18) and 85.7% (12 / 14), respectively. The difference was not statistically significant (蠂 ~ 2 / 0. 847). The plaques of shoulder, base and tail were 70.0 and 23.36.7respectively, the difference was statistically significant (蠂 ~ 2 ~ (29. 100) P ~ (0.001). The distribution ratio of enhanced plaques in each part was from high to low to the bottom of shoulder base (P ~ (0.001). There was a positive correlation between enhanced plaque and site order (r = 0.404, P 0.01). There was no significant difference in TTP between soft spot group and mixed spot group (t 0. 479 0. 05). The differences of PI and DE between soft spot group and mixed spot group were statistically significant (t = 7.497, P < 0.05). ConclusionContrast-enhanced ultrasonography can show the neovascularization in carotid atherosclerotic plaques, which is helpful to evaluate the vulnerability of plaque.
【作者单位】：昆明医科大学第二附属医院超声科;解放军总医院口腔颌面外科;昆明医科大学第二附属医院神经内科;
【基金】：国家自然科学基金项目(31271004)
【分类号】：R445.1;R543.4

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