磁共振成像表观扩散系数对乳腺癌新辅助化疗的疗效评估

发布时间：2019-01-16 08:45

【摘要】：目的探讨磁共振成像(MRI)表观扩散系数(ADC)对乳腺癌新辅助化疗(NAC)疗效的评估价值。方法选取2011年1月1日-2013年12月31日在该院行NAC的乳腺癌患者44例,比较患者NAC前和NAC4个周期后MRI测量肿瘤直径、ADC值变化及其相关性。结果所有患者完成4个周期的NAC,患者完全反应率(CR)为4.5%(2/44)、部分反应率(PR)为68.2%(30/44)、疾病稳定率(SD)为25.0%(11/44)、疾病进展率(PD)为2.3%(1/44);有反应率(CR+PR)为72.7%(32/44),无反应率(SD+PD)为27.3%(12/44);有反应组NAC前后肿瘤最大直径由(4.57±1.94)cm缩短为(3.03±2.21)cm,差异有统计学意义(P0.01);有反应组NAC前后ADC值由(0.91±0.28)×10-3mm2/s增加到(1.01±0.32)×10-3mm2/s,差异有统计学意义(P0.01);NAC前和NAC 4个周期后ADC值变化与肿瘤最大直径变化呈正相关(r=0.344,P0.05)。结论肿瘤最大直径变化直观地反映化疗疗效,MRI的ADC值从细胞水平量化化疗疗效,是评估化疗疗效的敏感指标。
[Abstract]:Objective to evaluate the value of (MRI) diffusion coefficient (ADC) in evaluating the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer. Methods 44 patients with breast cancer who underwent NAC from January 1, 2011 to December 31, 2013 were enrolled in this study. Tumor diameter, ADC value and their correlation were measured before NAC and after NAC4 cycles. Results the complete response rate (CR), partial response rate (PR) and disease stability rate (SD) were 4.5% (2 / 44), 68.2% (30 / 44) and 25.0% (11 / 44), respectively. The disease progression rate (PD) was 2.3% (1 / 44); The reaction rate (CR PR) was 72.7% (32 / 44) and the non-reactive rate (SD PD) was 27.3% (12 / 44). In the response group, the maximum diameter of tumor decreased from (4.57 卤1.94) cm to (3.03 卤2.21) cm, before and after NAC (P0.01). In the response group, ADC increased from (0.91 卤0.28) 脳 10-3mm2/s to (1.01 卤0.32) 脳 10 ~ (-3) mm ~ (2) / s, the difference was statistically significant (P0.01). There was a positive correlation between the change of ADC and the maximum diameter of tumor before NAC and after 4 cycles of NAC (r = 0.344P 0.05). Conclusion the maximum diameter change of tumor can directly reflect the curative effect of chemotherapy. The ADC value of MRI is a sensitive index to evaluate the curative effect of chemotherapy by quantifying the curative effect of chemotherapy from the cell level.
【作者单位】：广西医科大学第一附属医院胃肠腺体外科;广西医科大学第一附属医院放射科;
【基金】：广西壮族自治区卫生厅自筹经费项目(No:Z2011328)
【分类号】：R737.9;R445.2

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