剪切波弹性成像诊断甲状腺结节Meta分析

发布时间：2019-02-22 20:00

【摘要】：目的应用Meta分析评价剪切波弹性成像诊断甲状腺结节的价值。方法计算机检索PubMed、Nature、相关期刊论文CNKI和万方等数据库,收集关于甲状腺结节剪切波弹性成像的中英文文献,根据诊断性试验研究的纳入标准纳入和排除文献,应用Meta-Disc1.4软件对纳入的研究结果进行Meta分析并绘制汇总受试者工作特征(SROC)曲线,计算曲线下面积。结果最终纳入5篇文献、共586个甲状腺病灶,病理结果显示良性结节481个,恶性结节105个。剪切波弹性成像诊断甲状腺结节良恶性的敏感度0.84[95%CI(0.75~0.90)],特异度0.86[95%CI(0.83~0.89)],阳性似然比6.35[95%CI(2.64~15.24)],阴性似然比为0.20[95%CI(0.13~0.31)],诊断比值比31.21[95%CI(12.40~78.53)],诊断试验的SROC曲线下面积为0.9037(Q*=0.8353)。结论应用剪切波弹性成像诊断甲状腺结节的敏感度和特异度均较高,能够作为甲状腺结节的无创诊断方法。
[Abstract]:Objective to evaluate the value of shear wave elastography in the diagnosis of thyroid nodules by Meta analysis. Methods the full text databases of PubMed,Nature, CNKI and Wanfang were searched, and the Chinese and English literatures on Shear wave elastic imaging of thyroid nodules were collected, and the literatures were included and excluded according to the criteria of diagnostic test. The Meta-Disc1.4 software was used to analyze the results of the study by Meta and draw the (SROC) curve of the operating characteristics of the subjects and calculate the area under the curve. Results 586 thyroid lesions were included in 5 literatures. The pathological results showed that there were 481 benign nodules and 105 malignant nodules. The sensitivity and specificity of shear wave elastography for the diagnosis of benign and malignant thyroid nodules were 0.84 [95%CI (0.75 ~ 0.90)], 0.86 [95%CI (0.833 卤0.89)], and 6.35 [95%CI (2.64 卤15.24)]. The negative likelihood ratio was 0.20 [95%CI (0.13 ~ 0.31)] and the diagnostic ratio was 31.21 [95%CI (12.40 ~ 78.53)]. The area under the SROC curve of diagnostic test was 0.9037. Conclusion Shear wave elastography has high sensitivity and specificity in the diagnosis of thyroid nodules and can be used as a noninvasive method for the diagnosis of thyroid nodules.
【作者单位】：新疆医科大学附属肿瘤医院超声科;
【分类号】：R445.1;R581

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