RECIST1.0和mRECIST在肝癌射频消融术后疗效评价中的对比研究

发布时间：2019-04-12 15:41

【摘要】：目的:对肝癌患者经皮射频消融(RFA)术前、术后采用RECIST1.0和mRECIST测量比较,为肝癌患者RFA术后提供更准确的疗效评价方法。方法:23例(29个病灶)确诊为原发性肝癌患者至少做过1次RFA,分别于RFA术前1月内、术后3~6月内行CT或MR四期扫描,至少两名放射科医生参与阅片,根据RECIST1.0和m RECIST评价标准评估治疗的缓解、控制程度。两种方法评价疾病控制率的比较采用χ2检验。结果:采用RECIST1.0标准评价的完全缓解(CR)和部分缓解(PR)均为0例、疾病稳定(SD)为6例、疾病进展(PD)为23例,缓解率为00.00%,疾病控制率为20.69%;采用mRECIST标准评价肝癌RFA术后CR为25例、PR为2例、SD为1例、PD为1例,缓解率为93.11%,疾病控制率为96.56%,经χ2检验,P0.05,疾病控制率有显著性统计学差异。结论:RECIST1.0标准低估了肝癌RFA局部治疗效果,mRECIST标准强调治疗后动脉期强化存活肿瘤的测量,疗效评价更客观、可靠,对肿瘤术后的后续治疗有一定的指导意义。
[Abstract]:Aim: to compare the RECIST1.0 and mRECIST measurements before and after percutaneous radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC), so as to provide a more accurate method for evaluating the curative effect of patients with HCC after RFA. Methods: twenty-three patients (29 lesions) with primary liver cancer underwent at least one RFA, scan within 1 month before RFA and within 3 to 6 months after RFA. At least two radiologists were involved in the examination. According to the evaluation criteria of RECIST1.0 and m-RECIST, the remission and control degree of treatment were evaluated. 蠂 2 test was used to evaluate the disease control rate between the two methods. Results: the complete remission (CR) and partial remission (PR) evaluated by RECIST1.0 criteria were 0 cases, the disease stable (SD) was 6 cases, the disease progression (PD) was 23 cases, the remission rate was 0.000%, and the disease control rate was 20.69%. There were 25 cases of CR, 2 cases of PR, 1 case of SD, 1 case of PD, the remission rate was 93.11%, the rate of disease control was 96.56%. The 蠂 ~ 2 test showed that there was significant difference in the rate of disease control. Conclusion: RECIST1.0 standard underestimates the effect of local treatment for hepatocellular carcinoma (RFA), and mRECIST standard emphasizes the measurement of enhanced survival tumor in arterial phase after treatment. The evaluation of therapeutic effect is more objective and reliable. It has certain guiding significance for the follow-up treatment of HCC after operation.
【作者单位】：中国医科大学附属第一医院放射科;宁夏人民医院放射科;
【分类号】：R735.7;R730.44

【参考文献】