超声射频信号技术评价高密度脂蛋白胆固醇对颈动脉结构和弹性功能的影响

发布时间：2019-04-21 19:43

【摘要】：目的探讨超声射频信号定量技术评价血脂异常患者颈总动脉内-中膜厚度(IMT)和弹性改变及高密度脂蛋白胆固醇(HDL-C)对颈总动脉结构和弹性功能的影响。资料与方法选取血脂异常患者150例作为高脂血症组,分为高血脂伴HDL-C升高50例(A组)、高血脂而HDL-C正常50例(B组)、高血脂伴HDL-C降低50例(C组),同期选取体检健康者50例作为对照组(D组)。应用超声射频信号技术分析高脂血症及HLD-C对颈总动脉IMT及弹性参数顺应性系数(CC)、僵硬度指数(β)、脉搏波传导速度(PWV)、动脉反射波增强指数(AIx)的影响。结果 B组IMT、β、PWV、AIx较D组增高,CC降低,差异有统计学意义(t=5.141、4.219、4.898、4.142、-3.758,P0.05)。B组的IMT、β、PWV、AIx较A组升高,CC较A组降低,差异均有统计学意义(t=3.425、2.807、2.913、2.209、-2.091,P0.05、P0.01);C组的IMT、β、PWV、AIx较B组升高,CC较B组降低,差异均有统计学意义(t=4.937、2.195、3.337、2.067、-3.049,P0.05、P0.01));A组IMT、PWV较D组升高,差异均有统计学意义(t=2.236、2.407,P0.05),而CC、β、AIx与D组比较差异无统计学意义(t=-1.693、1.845、1.967,P0.05)。HDL-C升高可降低高血脂患者颈动脉IMT和僵硬度,升高弹性,反之颈动脉IMT和僵硬度增加,弹性下降。结论超声射频信号技术能够自动、实时、准确测量血脂异常患者颈总动脉IMT和动脉弹性,可为临床评价动脉早期结构和功能变化及调脂治疗提供较为准确的定量指标。
[Abstract]:Objective to evaluate the changes of carotid intima-media thickness (IMT) and elasticity in patients with dyslipidemia and the effect of high density lipoprotein cholesterol (HDL-C) on the structure and elastic function of common carotid artery. Materials and methods 150 patients with dyslipidemia were divided into hyperlipidemia group (group A), hyperlipidemia with HDL-C elevation (group A), hyperlipidemia with normal HDL-C (group B), and hyperlipidemia with HDL-C decrease (group C). At the same time, 50 healthy subjects were selected as control group (group D). The effects of hyperlipidemia and HLD-C on (CC), stiffness index (尾) and pulse wave conduction velocity (PWV),) arterial reflection wave enhancement index (AIx) of common carotid artery (CCA), compliance coefficient (CC),) and pulse wave conduction velocity (PWV),) were analyzed by radio frequency ultrasound (RF) technique. Results the levels of IMT, 尾 and PWV,AIx in group B were significantly higher than those in group D (t = 5.141, 4.219, 4.898, 4.142, and 3.758, respectively). The levels of IMT, 尾 and PWV,AIx in group). B were higher than those in group A, while the level of CC in group). B was lower than that in group A. The differences were statistically significant (t = 3.425, 2.807, 2.913, 2.209, 2.091, P 0.05, P0.01); The levels of IMT, 尾 and PWV,AIx in group C were higher than those in group B, while the CC in group B were lower than those in group B (t = 4.937, 2.195, 3.337, 2.067, 3.049, P 0.05, P0.01);). IMT,PWV in group A was significantly higher than that in group D (t = 2.236, 2.407, P0.05), but there was no significant difference in CC, 尾 and AIx between group A and group D (t = 1.693, 1.845, 1.967, P < 0.05), but there was no significant difference between group A and group D (t = 1.693, 1.845,1.967). The increase of HDL-C could decrease the IMT and stiffness of carotid artery and increase the elasticity of patients with hyperlipidemia. On the other hand, the increase of IMT and stiffness of carotid artery decreased the elasticity of carotid artery. Conclusion Ultrasound radiofrequency signal technique can automatically, real-time and accurately measure the common carotid artery IMT and arterial elasticity in patients with dyslipidemia. It can provide a more accurate quantitative index for the clinical evaluation of the early changes of arterial structure and function and the treatment of lipid regulation.
【作者单位】：广东省人民医院广东省医学科学院超声科;
【基金】：广东省企业技术研发与升级改造专项资金项目(2013B021800156)
【分类号】：R445.1;R589.2

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