钆塞酸二钠增强磁共振对肝癌TACE术后局部肝功能损伤的评价
发布时间：2019-05-14 04:31
【摘要】：目的：探讨应用钆塞酸二钠(Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid, Gd-EOB-DTPA)增强核磁共振(Magnetic resonance imaging, MRI)扫描评价肝细胞癌(Hepatocellular carcinoma, HCC)行经导管动脉灌注化疗栓塞(Transcatheter arterial chemoembolization, TACE)术后局部肝功能损伤的价值。 方法：对29例HCC的患者于TACE术后3-5天以及随访1-2月后行MR扫描,测量平扫和Gd-EOB-DTPA增强后20分钟(肝细胞期)肿瘤周边(3厘米以内)组织以及正常肝组织的信噪比值(Signal to noise ratio, SNR),将二者进行对比。同时将可能的影响因素,如患者年龄、性别、肿瘤直径、肿瘤血供情况、Chind-Pugh分级和碘油栓塞量与结果进行多因素相关分析。 结果：TACE术后3-5天,平扫肿瘤周边组织的SNR值与正常肝组织的SNR差异无统计学意义(t=1.341, P=0.191), Gd-EOB-DTPA增强后20分钟肿瘤周边组织的SNR值明显低于正常肝组织的SNR值(t=3.732,P0.001)。TACE术后1-2月复查MRI,平扫肿瘤周边组织的SNR值与正常肝组织的SNR值差异无统计学意义(t=0.189,P=0.852); Gd-EOB-DTPA增强后20分钟肿瘤周边的SNR与正常肝组织的SNR值差异同样无统计学意义(t=1.535,P=0.136)。局部肝功能损伤的程度与患者年龄、性别、肿瘤直径、肿瘤血供情况、Chind-Pugh分级均无明显相关性,碘油栓塞量是唯一影响局部肝功能损伤程度的因素。 结论：Gd-EOB-DTPA增强MRI扫描是一种有效评价肝癌TACE术后局部肝功能损伤的方法,对指导进一步治疗有着重要价值。图6幅,表6个,参考文献45篇
[Abstract]:Objective: to investigate the evaluation of transcatheter arterial infusion chemoembolism (Transcatheter arterial chemoembolization,) in hepatocellular carcinoma (Hepatocellular carcinoma, HCC) by enhanced nuclear magnetic resonance (Magnetic resonance imaging, MRI) with disodium gadolinium citrate (Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid, Gd-EOB-DTPA). TACE) the value of local liver function injury after operation. Methods: 29 patients with HCC were examined by MR at 3 to 5 days after TACE and 1-2 months after follow-up. The signal-to-noise ratio (SNR) (Signal to noise ratio, SNR), of peripheral tissues (less than 3 cm) and normal liver tissues (within 3 cm) were measured 20 minutes after Gd-EOB-DTPA enhancement. At the same time, the possible influencing factors, such as patient age, sex, tumor diameter, tumor blood supply, Chind-Pugh grade and iodized oil embolic volume, were analyzed by multivariate correlation analysis. Results: there was no significant difference in SNR between the surrounding tissues of the tumor and the normal liver tissue at 3 and 5 days after TACE (t 鈮，
本文编号：2476437
[Abstract]:Objective: to investigate the evaluation of transcatheter arterial infusion chemoembolism (Transcatheter arterial chemoembolization,) in hepatocellular carcinoma (Hepatocellular carcinoma, HCC) by enhanced nuclear magnetic resonance (Magnetic resonance imaging, MRI) with disodium gadolinium citrate (Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid, Gd-EOB-DTPA). TACE) the value of local liver function injury after operation. Methods: 29 patients with HCC were examined by MR at 3 to 5 days after TACE and 1-2 months after follow-up. The signal-to-noise ratio (SNR) (Signal to noise ratio, SNR), of peripheral tissues (less than 3 cm) and normal liver tissues (within 3 cm) were measured 20 minutes after Gd-EOB-DTPA enhancement. At the same time, the possible influencing factors, such as patient age, sex, tumor diameter, tumor blood supply, Chind-Pugh grade and iodized oil embolic volume, were analyzed by multivariate correlation analysis. Results: there was no significant difference in SNR between the surrounding tissues of the tumor and the normal liver tissue at 3 and 5 days after TACE (t 鈮，
本文编号：2476437
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