磁敏感加权成像评价帕金森病针药联合治疗的效果

发布时间：2019-08-05 15:50

【摘要】：目的探讨磁敏感加权成像(SWI)对治疗帕金森病(PD)疗效评价的应用价值。方法对符合纳入标准的20例PD患者行针刺穴位及药物联合治疗6个疗程,治疗前、后行UPDRS评分。应用SWI序列技术对所有病例治疗前后的苍白球(GP)、壳核(PUT)、尾状核(CN)、黑质(SN)、红核(RN)的体积及铁含量的相位位移值进行测量,所得数据行配对t检验。结果 PD患者治疗后UPDRS评分明显减低(P0.01)。与治疗前比较苍白球(GP)、壳核(PUT)体积(感兴趣区ROI)增大(P0.01),苍白球(GP)、壳核(PUT)、黑质网状带(SNr)相位值变化明显(P0.01)。结论应用磁敏感加权成像序列技术测量核团体积与相位位移值结果客观可靠,可弥补UPDRS评分量表不足,对PD疗效评价具有较高的应用价值。
[Abstract]:Objective To evaluate the value of magnetic sensitive weighted imaging (SWI) in the treatment of PD. Methods A total of 20 PD patients who met the criteria were treated with acupuncture points and drugs for 6 courses, before and after treatment. The phase shift of the volume and the iron content of the globus pallidus (GP), the shell core (PUT), the caudate nucleus (CN), the substantia nigra (SN) and the red nucleus (RN) before and after the treatment of all cases was measured by the SWI sequence technique, and the obtained data line paired t test. Results The scores of post-treatment and post-treatment of patients with PD were significantly lower (P0.01). The change of the phase value of the white ball (GP), the shell core (PUT) volume (region of interest ROI) was increased (P 0.01), the white ball (GP), the shell core (PUT) and the black mesh belt (SNr) in comparison with the treatment before treatment (P0.01). Conclusion Magnetic sensitive weighted imaging sequence technique is used to measure the objective and reliable results of the phase displacement of nuclear group and can be used to make up for the deficiency of the RRS score, and has high application value to the evaluation of PD.
【作者单位】：黑龙江中医药大学附属第一医院CT磁共振科;黑龙江中医药大学;哈尔滨医科大学;
【基金】：国家自然科学基金面上项目(No.81373714) 黑龙江省中医药科研项目(No.ZHY12-Z046) 黑龙江省自然科学基金面上项目(No.D201214)
【分类号】：R742.5;R445.2

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