卵巢癌患者化疗前后血清中糖类抗原125肿瘤坏死因子α和可溶性白细胞介素2受体检测的临床意义

发布时间：2017-12-28 10:37

本文关键词：卵巢癌患者化疗前后血清中糖类抗原125肿瘤坏死因子α和可溶性白细胞介素2受体检测的临床意义　出处：《中国肿瘤临床与康复》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨卵巢癌患者化疗前后血清中糖类抗原125(CA125)、肿瘤坏死因子(TNF-α)和可溶性白细胞介素2受体(SIL-2R)检测的临床意义。方法选取2014年4月至2015年2月间扶风县人民医院妇产科收治的卵巢癌患者、妇科良性肿瘤患者及健康体检者各30例,采用放射免疫分析法进行检测。结果卵巢癌患者血清中CA125、TNF-α及SIL-2R与良性肿瘤患者和健康体检者比较,指标明显升高,差异均有统计学意义(均P0.05)。卵巢癌患者CA125、TNF-α和SIL-2R治疗前分别为(265.0±189.5)μg/L、(1.98±0.79)μg/L和(452.3±22.0)U/m L,治疗后为(89.8±51.3)μg/L、(0.91±0.29)μg/L和(209.7±101.2)U/m L,差异均有统计学意义(均P0.05)。结论治疗前后血清中CA125、TNF-α和SIL-2R的表达水平对卵巢癌患者的诊断、治疗和预后有重要临床意义。
[Abstract]:Objective to investigate the clinical significance of serum carbohydrate antigen 125 (CA125), tumor necrosis factor (TNF-) and soluble interleukin 2 receptor (SIL-2R) in patients with ovarian cancer before and after chemotherapy. Methods from April 2014 to February 2015, 30 cases of ovarian cancer, gynecologic benign tumor patients and health checkup patients in gynecology and obstetrics department of Fufeng people's hospital were detected by radioimmunoassay. Results the serum levels of CA125, TNF- and SIL-2R in patients with ovarian cancer were significantly higher than those in benign tumor patients and healthy controls, with statistically significant difference (P0.05). The levels of CA125, TNF- and SIL-2R before treatment were respectively (265 + 189.5) mu g/L, (1.98 + 0.79) mu g/L and (452.3 + 22) U/m L before treatment. After treatment, there were (89.8 + 51.3) g/L, 0.91 0.91 0.29 g/L and 209.7 209.7 U/m L. Conclusion the expression level of CA125, TNF- alpha and SIL-2R in serum before and after treatment has important clinical significance for the diagnosis, treatment and prognosis of ovarian cancer patients.
【作者单位】：陕西省扶风县人民医院妇产科;陕西省肿瘤医院妇科;
【分类号】：R737.31
【正文快照】： 710061)卵巢癌是女性生殖器官常见肿瘤之一,一般认为与年龄、精神等多种因素有关[1]。随着现代科学的不断进步,临床对于卵巢癌的诊断方法也在不断更新。目前,最常见的检查方法除盆腔检查外,血清中糖类抗原125(CA125)、肿瘤坏死因子α(TNF-α)及可溶性白细胞介素2受体(SIL-2R)

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