慢性乙型肝炎孕妇HBeAg阳性与不良妊娠结局关系研究

发布时间：2017-12-28 12:15

本文关键词：慢性乙型肝炎孕妇HBeAg阳性与不良妊娠结局关系研究　出处：《中国实用妇科与产科杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的分析慢性乙型肝炎病毒(HBV)感染孕妇不同HBe Ag血清学状态对不良妊娠结局的影响。方法回顾性调查2010年1月1日至2015年12月31日于南方医科大学南方医院分娩的440例HBs Ag(+)孕妇,将其分为HBe Ag(+)265例,HBe Ag(-)175例,随机选取同时期非HBV感染健康孕妇304例作对照组,分析各组不良妊娠结局的差异。另将378例HBV携带孕妇按HBV DNA是否≥1.0×10~6U/L,分为HBV DNA(+)174例及HBV DNA(-)204例,进一步比较两组不良妊娠结局的差异。结果 HBe Ag(+)组比非HBV感染健康孕妇组早产或胎膜早破发生风险更高,HBe Ag(-)组与非HBV感染健康孕妇组不良妊娠结局发生风险没有显著差异;HBV DNA(+)组早产、胎膜早破发生率分别为10.92%、13.22%,HBV DNA(-)组为3.43%、6.37%(P=0.004,P=0.024)。结论 HBe Ag(+)孕妇发生早产或胎膜早破风险高于HBe Ag(-)孕妇,HBe Ag(+)可作为预测早产或胎膜早破发生风险的高危因素。
[Abstract]:Objective to analyze the effect of different HBe Ag serological status on adverse pregnancy outcomes in pregnant women with chronic hepatitis B virus (HBV) infection. 440 cases of HBs Ag retrospective survey methods from January 1, 2010 to December 31, 2015 in the delivery of Nanfang Hospital of Southern Medical University (+) in pregnant women, which can be divided into HBe Ag (+) 265 cases, HBe Ag (-) 175 cases, randomly selected the same period of non HBV infection and 304 cases of healthy pregnant women as control group, the differences were analyzed for adverse pregnancy outcomes. The other 378 cases of pregnant women with HBV by HBV DNA is over 1 * 10~6U/L, divided into HBV DNA (+) in 174 cases of HBV and DNA (-) 204 cases, further comparison of two groups of adverse pregnancy outcome differences. The results of HBe Ag (+) HBV infection group than in healthy pregnant women group or preterm premature rupture of membranes had higher risks, HBe Ag (-) group and non HBV infection group of healthy pregnant women with adverse pregnancy outcomes have no significant difference in the risk; HBV DNA (+) group, the incidence of preterm premature rupture of membranes were 10.92% and 13.22%. HBV DNA (-) group was 3.43% and 6.37% (P=0.004, P=0.024). Conclusion the risk of premature delivery or premature rupture of membranes in pregnant women with HBe Ag (+) is higher than that in HBe Ag (-) pregnant women. HBe Ag (+) can be used as a risk factor for predicting the risk of premature delivery or premature rupture of membranes.
【作者单位】：南方医科大学南方医院妇产科;南方医科大学第一临床医学院;
【基金】：国家自然科学基金(81401208)
【分类号】：R714.251
【正文快照】：

【参考文献】