TCT与高危型HPV-DNA检测在宫颈癌筛查中的应用价值探讨

发布时间：2018-01-01 18:29

本文关键词：TCT与高危型HPV-DNA检测在宫颈癌筛查中的应用价值探讨　出处：《中国妇幼保健》2016年24期 　论文类型：期刊论文

【摘要】：目的探讨液基薄层细胞学检查(TCT)与高危型人乳头状瘤病毒(HPV)-DNA检测在宫颈癌筛查中的应用价值。方法选取696例在盐城市妇幼保健院进行宫颈癌筛查的妇女作为研究对象,均进行宫颈TCT和HPV-DNA检测,并在阴道镜下取宫颈活体组织进行病理学诊断,分析TCT和HPV-DNA检测对宫颈癌的诊断结果。结果 TCT诊断宫颈癌的准确性、敏感性、特异性、阳性预测值、阴性预测值分别为76.15%、75.15%、77.05%、74.70%、77.47%;HPV-DNA检测诊断宫颈癌的准确性、敏感性、特异性、阳性预测值、阴性预测值分别为85.78%、90.00%、81.97%、81.82%、90.09%。与TCT相比,HPV-DNA检测诊断宫颈癌的敏感性、阴性预测值明显更高(P0.05)。HPV-DNA+TCT诊断宫颈癌的准确性、敏感性、特异性、阳性预测值、阴性预测值分别为89.80%、97.27%、83.06%、83.81%、97.12%。与单纯HPV-DNA和单纯TCT相比,HPV-DNA+TCT诊断宫颈癌的敏感性明显更高(P0.05),同时准确性、特异性、阳性预测值、阴性预测值也有所提高。结论 TCT和HPV-DNA检测都是宫颈癌筛查的有效手段,二者联用能够有效提高诊断宫颈癌的敏感性,降低漏诊率,具有重要的临床应用价值。
[Abstract]:Objective to investigate the ThinPrep cytology test (TCT) and human papilloma virus (HPV) value of -DNA detection in the screening of cervical cancer. Methods 696 cases of women for cervical cancer screening in Yancheng Maternal and Child Health-Care Center as the research object, both for cervical TCT and HPV-DNA detection, and the pathological diagnosis of cervical in vivo in colposcopy, TCT and HPV-DNA detection in the diagnosis of cervical cancer. The analysis results of TCT cervical cancer diagnosis accuracy, sensitivity, specificity, positive predictive value, negative predictive value were 76.15%, 75.15%, 77.05%, 74.70%, 77.47%; the accuracy of HPV-DNA diagnosis of cervical cancer, detection sensitivity, specificity, positive predictive value, negative predictive value were 85.78%, 90%, 81.97%, 81.82%, 90.09%. compared with TCT, the sensitivity of HPV-DNA detection in the diagnosis of cervical cancer, the negative predictive value was significantly higher (P0.05).HPV-DNA+TCT diagnosis The accuracy of cervical cancer, sensitivity, specificity, positive predictive value, negative predictive value were 89.80%, 97.27%, 83.06%, 83.81%, 97.12%. compared with pure HPV-DNA and pure TCT, the sensitivity of HPV-DNA+TCT diagnosis of cervical cancer was significantly higher (P0.05) at the same time, accuracy, specificity, positive predictive value, negative predictive value is improve. Conclusion TCT and HPV-DNA detection are effective methods of cervical cancer screening, can effectively improve the sensitivity of diagnosis of cervical cancer with the combination of the two, reduce the rate of misdiagnosis, has important clinical value.

【作者单位】：盐城市妇幼保健院妇科;
【分类号】：R737.33
【正文快照】： 子宫颈癌是临床常见的女性恶性肿瘤之一,其发病率在女性恶性肿瘤中居第2位,会对女性的生理健康及生命安全造成严重危害。本病的发生、发展是一个漫长的过程,这一过程可能是三五年,也可能是十余年,若能在宫颈癌发生的早期确诊并采取有效的治疗措施,九成以上的患者可治愈[1]。我

【相似文献】