年轻女性宫颈人乳头瘤病毒感染亚型与宫颈病变的调查

发布时间：2018-01-01 23:32

本文关键词：年轻女性宫颈人乳头瘤病毒感染亚型与宫颈病变的调查　出处：《癌症进展》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨年轻女性(年龄25~35岁)人乳头瘤病毒(HPV)感染亚型与宫颈病变的特点。方法采集1273例患者宫颈上皮细胞标本,采用PCR-反向点杂交法对其进行21种HPV分型的检测。结果 1273例年轻女性患者,HPV阳性有130例,检出率为10.2%;单一型感染为115例,包括高危型感染105例,感染率为91.3%,低危型感染10例,感染率为8.7%;最常见高危型是HPV16,共35例,其次为HPV58,共17例;HPV16感染导致宫颈高级别上皮内瘤变10例,低级别上皮内瘤变11例;高危HPV阳性患者,宫颈活检证实为鳞状细胞癌的病例2例,均是HPV16感染。结论年轻女性HPV阳性检出率较高,以单一型感染和高危型感染为主,高危型HPV感染与宫颈高级别上皮内瘤变和宫颈癌的发生密切相关,其中HPV16亚型是导致年轻女性宫颈癌的主要原因。
[Abstract]:Objective to investigate the subtypes of human papillomavirus (HPV) infection and the characteristics of cervical lesions in young women (25 ~ 35 years old). The results showed that 130 of 1273 young female patients were positive for HPV, the detection rate was 10.2%. There were 115 cases of single type infection, including 105 cases of high risk type infection, the infection rate was 91.3%, 10 cases of low risk type infection, the infection rate was 8.7%. The most common high-risk type was HPV16 (35 cases), followed by HPV58 (17 cases). HPV16 infection caused cervical intraepithelial neoplasia in 10 cases and low grade intraepithelial neoplasia in 11 cases. Two cases of squamous cell carcinoma confirmed by cervical biopsy were HPV16 infection. Conclusion the positive rate of HPV in young women is higher, mainly single type infection and high risk type infection. High risk HPV infection is closely related to cervical intraepithelial neoplasia and cervical cancer, among which HPV16 subtype is the main cause of cervical cancer in young women.
【作者单位】：青海省人民医院病理科;北京协和医学院医务室全科医学门诊;
【分类号】：R737.33
【正文快照】： 2北京协和医学院医务室全科医学门诊,北京1007300Oncol Prog,2016,14(12)宫颈癌居女性常见肿瘤的第二位,人乳头瘤病毒(human papillomavirus,HPV)慢性感染是导致宫颈癌发生的必须条件[1-2]。研究统计,随着医学实验技术的发展,临床液基薄层细胞检测(thinprep cyto-logic test,T

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