多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症的治疗效果及对妊娠结局的影响

发布时间：2018-01-02 22:34

本文关键词：多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症的治疗效果及对妊娠结局的影响　出处：《中国妇幼保健》2016年24期 　论文类型：期刊论文

【摘要】：目的探讨多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症的治疗效果及对妊娠结局的影响。方法选择2015年2月-2016年2月接诊的妊娠期肝内胆汁淤积症患者80例,通过随机数表法分为观察组和对照组各40例,对照组患者给予熊去氧胆酸+腺苷蛋氨酸治疗,观察组患者在此基础上加用多烯磷脂酰胆碱。观察两组患者治疗前、后肝功能、瘙痒积分变化及瘙痒、黄疸消失时间,并比较两组患者妊娠结局及新生儿结局。结果治疗后,观察组丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、血清总胆汁酸(TBA)均低于对照组,瘙痒积分(1.01±0.23)低于对照组的(1.95±0.27),瘙痒消失、黄疸消失时间均比对照组短,差异均有统计学意义(P0.05);观察组分娩孕周比对照组长,剖宫产率27.5%低于对照组的40.0%,差异有统计学意义(P0.05);观察组宫内窘迫、早产、新生儿窒息、产后出血的发生率均比对照组低,新生儿体重高于对照组,差异有统计学意义(P0.05)。结论在妊娠期肝内胆汁淤积症患者中,给予多烯磷脂酰胆碱的治疗效果优异,可使妊娠结局得到有效的改善,值得应用推广。
[Abstract]:Objective to investigate the therapeutic effect of polyenylphosphatidylcholine on intrahepatic cholestasis of pregnancy and its effect on pregnancy outcome. Methods Intrahepatic cholestasis of pregnancy was selected from February 2015 to February 2016. There were 80 cases. The patients in the control group were treated with adenosylmethionine ursodeoxycholate. The patients in the observation group were treated with polyenylphosphatidylcholine on this basis. The liver function, the change of itching score and the time of disappearance of pruritus and jaundice were observed before and after treatment in both groups. Results after treatment, the levels of alanine aminotransferase (alt), alanine aminotransferase (alt), aspartate aminotransferase (AST) and serum total bile acid (TBA) in the observation group were lower than those in the control group. The score of itching (1.01 卤0.23) was lower than that of control group (1.95 卤0.27). The time of disappearance of pruritus and jaundice was shorter than that of control group (P 0.05). The rate of cesarean section in the observation group was lower than that in the control group (P < 0.05), and the rate of cesarean section was lower than that in the control group (P < 0.05). The incidence of intrauterine distress, premature delivery, neonatal asphyxia and postpartum hemorrhage in the observation group was lower than that in the control group, and the weight of the newborn was higher than that in the control group. Conclusion in the patients with intrahepatic cholestasis of pregnancy, the effect of polyenylphosphatidylcholine is excellent, and the pregnancy outcome can be effectively improved. It is worth applying and popularizing.
【作者单位】：武汉大学人民医院钟祥医院;钟祥市人民医院;
【分类号】：R714.255
【正文快照】： 在妊娠中、晚期,妊娠期肝内胆汁淤积症(In-trahepatic cholestasis of pregnancy,ICP)较为常见,该病主要是由于胆汁无法良好的排除,使之在胆道内发生淤积,导致患者出现皮肤瘙痒、黄疸、血清胆汁酸升高的症状[1]。该病易对胎儿造成较大影响,会引发早产、新生儿窒息、宫内窘迫等

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