妇科原发性小细胞癌八例临床分析
发布时间:2018-01-03 06:33
本文关键词:妇科原发性小细胞癌八例临床分析 出处:《中华肿瘤防治杂志》2016年03期 论文类型:期刊论文
【摘要】:目的妇科原发性小细胞癌病例罕见,预后差。结合北京大学第三医院病例探讨妇科原发性小细胞癌的发病特点以及诊断治疗方案。方法回顾性分析2006-01-01-2015-08-31北京大学第三医院收治的经病理确诊的8例妇科原发性小细胞癌患者的临床特征、治疗方案以及预后。结果患者年龄16~71岁,中位年龄43岁。常见症状包括阴道异常出血、腹痛、腹部包块等。诊断主要依靠手术病理确诊,其中宫颈小细胞癌ⅠB 1期2例,ⅠB 2期2例,ⅢB期1例;卵巢小细胞癌ⅢC期1例;子宫内膜小细胞癌Ⅳ期2例。治疗方案包括手术、化疗和放疗。手术方式参照相应部位肿瘤的治疗原则,有5例行广泛子宫切除术,2例行肿瘤细胞减灭术,1例因高龄伴高血压未行手术。7例手术患者中有3例接受术前化疗,7例术后均辅助化疗,有5例辅助术后放疗。随访至2015-12-20,无患者失访。有3例生存,分别随访22、22和56个月;5例死亡,生存期分别为2、8、10、22和31个月。患者疾病无进展生存时间(progression-free survival,PFS)为0.3~56个月,中位PFS为15个月,总生存时间(overall survival,OS)为2~56个月,中位OS为22个月。结论妇科小细胞癌术前影像学检查常有淋巴结转移,其确诊依靠组织病理学检查。该肿瘤预后差,手术是早期病变的主要治疗手段,晚期病例宜采用手术、化疗和放疗相结合的综合治疗。
[Abstract]:Objective Primary small cell carcinoma of gynecology is rare. The prognosis was poor. To discuss the characteristics of gynecological primary small cell carcinoma and its diagnosis and treatment with the case of Peking University third Hospital. Methods retrospective analysis of 2006-01-2015-08-31 North China. Clinical features of 8 patients with gynecological primary small cell carcinoma admitted to the third Hospital of Beijing University. Results the age of the patients was 1671 years old and the median age was 43 years old. The common symptoms included abnormal vaginal bleeding abdominal pain abdominal mass and so on. The diagnosis was mainly based on surgery and pathology. There were 2 cases of small cell carcinoma of the cervix in stage 鈪,
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