三种促排卵方案对卵巢储备力低下患者助孕效果比较

发布时间：2018-01-05 01:27

本文关键词：三种促排卵方案对卵巢储备力低下患者助孕效果比较　出处：《现代妇产科进展》2016年11期 　论文类型：期刊论文

【摘要】：目的:探讨卵巢储备力低下患者行体外受精/卵胞浆内单精子显微注射-胚胎移植(IVF/ICSI-ET)助孕时较理想的超促排卵方案。方法:将302例行IVF/ICSI-ET助孕的卵巢储备力低下患者分为3组:微刺激方案组(A组,98例)、黄体期促排卵方案组(B组,62例)和超短方案组(C组,142例),比较3组的一般情况、周期取消率、总促性腺激素释放激素(Gn)使用天数(Gn天数)、人绒毛膜促性腺激素(HCG)日血雌二醇(E_2)、促黄体生成素(LH)、孕酮(P)及子宫内膜厚度、平均获卵数、受精率、形成胚胎率、优质胚胎率、临床妊娠率、生化妊娠率。结果:A组的周期取消率均明显高于B、C两组(P0.05);A组的总Gn天数最短,C组的总Gn天数最长(P0.05);A组的HCG日子宫内膜厚度低于B、C组,但差异无统计学意义;A组的HCG日E_2水平、平均获卵数均低于B、C两组,C组的HCG日LH水平均低于A、B两组(P0.05)。3组的一般情况、正常受精率、成胚率、优胚率、临床妊娠率、生化妊娠率均无统计学差异。结论:超短方案可能是较好的卵巢储备力低下超促排卵方案,同时黄体期促排卵亦不失为一种新的有效促排卵方案。
[Abstract]:Objective: to investigate in vitro fertilization / intracytoplasmic sperm microinjection (IVF / ICSI-ETT) in patients with low ovarian reserve. Methods: 302 patients with IVF/ICSI-ET were divided into three groups: group A and group A. There were 98 cases of ovulation promotion in luteal phase, 62 cases in group B and 142 cases in group C in ultrashort group. The general situation of group 3 and the rate of cycle cancellation were compared. Total gonadotropin releasing hormone (Gn) was used for days and HCG was used for days. Serum estradiol (E _ (2)) and luteinizing hormone (LH) were observed on the day of HCG (human chorionic gonadotropin) (HCG). P) and endometrial thickness, average number of eggs obtained, fertilization rate, embryo formation rate, high quality embryo rate, clinical pregnancy rate and biochemical pregnancy rate. Results the rate of cycle cancellation in group A was significantly higher than that in group B. Group C, P 0.05; Group A had the shortest total Gn days and group C had the longest total Gn days (P0.05); The thickness of endometrium in group A was lower than that in group C on HCG day, but the difference was not statistically significant. The average number of eggs obtained in group A was lower than that in group C (HCG day LH), which was lower than that in group A (group A) and group B (P 0.05.3), and the normal fertilization rate was also lower than that in group A (group A). The rate of embryo formation, the rate of superior embryo, the rate of clinical pregnancy and the rate of biochemical pregnancy were not statistically different. Conclusion: ultrashort regimen may be a better regimen of ovarian reserve capacity and hyperstimulation of ovulation. At the same time, ovulation promotion in luteal phase is also a new effective ovulation promotion program.
【作者单位】：青岛大学附属医院生殖医学科;
【分类号】：R714.8
【正文快照】： 育龄女性卵巢储备功能下降(diminished ovarian reserve,DOR)是指卵巢产生卵母细胞的能力和质量下降,从而导致生育能力低下,约占不孕不育症行辅助生殖技术(assisted reproductive technology,ART)的10%。DOR患者在行IVF/ICSI-ET助孕过程中常出现卵巢低反应(poor ovarian respo

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