温肾疏肝法联合克罗米芬治疗肾虚肝郁型PCOS所致不孕症临床观察

发布时间：2018-01-05 18:31

本文关键词：温肾疏肝法联合克罗米芬治疗肾虚肝郁型PCOS所致不孕症临床观察　出处：《山东中医药大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:观察温肾疏肝法联合克罗米芬治疗肾虚肝郁型PCOS所致不孕症的临床疗效,并探讨其作用机理。方法:将60例辨证属肾虚肝郁型PCOS所致不孕症患者随机分为两组,治疗组30例,分期序贯口服滋肾益精方和温肾疏肝方,同时口服克罗米芬;对照组30例,仅口服克罗米芬。连续服药3个月经周期。观察治疗前后患者中医证候改善情况,女性生殖激素变化,排卵情况及妊娠情况。结果:综合疗效比较,治疗组总有效率为86.67%,对照组总有效率为66.67%,统计分析治疗组疗效优于对照组(P0.05);中医证候疗效比较,治疗组总有效率90.00%,对照组总有效率66.67%,差异具有极显著性(P0.01);治疗组妊娠率为46.66%,对照组妊娠率20.00%,两组比较差异有显著性(P0.05);两组周期排卵率差异无显著性(P0.05);治疗组可增厚排卵日子宫内膜,统计分析优于对照组(P0.05);两组治疗后血T、LH、LH/FSH值均明显降低,治疗组与对照组比较T、LH、LH/FSH差异有显著性(P0.05)。结论:温肾疏肝法联合克罗米芬治疗肾虚肝郁型PCOS所致不孕症,能有效改善中医证候及临床症状、体征,调节女性生殖激素水平,增加排卵日子宫内膜厚度,提高妊娠率。
[Abstract]:Objective: to observe the clinical effect of warming the kidney and soothing the liver combined with clomiphene in the treatment of infertility caused by PCOS with kidney deficiency and liver depression. Methods: 60 cases of infertility caused by kidney deficiency and liver depression type were randomly divided into two groups: treatment group (n = 30) with sequential oral administration of Zishen Yijing recipe and Wenshen Shugan recipe by stages. Clomiphene; 30 patients in the control group were treated with clomiphene for 3 consecutive menstrual cycles. The improvement of TCM syndromes and the changes of female reproductive hormones were observed before and after treatment. Results: compared with the comprehensive curative effect, the total effective rate of the treatment group was 86.677.The total effective rate of the control group was 66.67%. The curative effect of the treatment group was better than that of the control group (P 0.05). The total effective rate was 90.00g in the treatment group and 66.67g in the control group. The difference was significant (P 0.01). The pregnancy rate in the treatment group was 46.66 and the pregnancy rate in the control group was 20.00. There was a significant difference between the two groups (P 0.05). There was no significant difference in the rate of ovulation between the two groups (P 0.05). The endometrium was thickened and ovulated in the treatment group, and the statistical analysis was better than that in the control group (P 0.05). After treatment, the blood THH / LH / FSH values in both groups were significantly lower than those in the control group. The difference of LH/FSH is significant (P0.050.Conclusion: the treatment of infertility caused by PCOS with kidney deficiency and liver depression can effectively improve TCM syndromes and clinical symptoms and signs. Regulate female reproductive hormone level, increase endometrial thickness on ovulation day, increase pregnancy rate.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R711.75

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