细胞溶解性阴道病的诊治进展

发布时间：2018-01-07 16:30

本文关键词：细胞溶解性阴道病的诊治进展　出处：《实用妇产科杂志》2016年12期 　论文类型：期刊论文

【摘要】：乳杆菌是女性阴道正常菌群中的重要成员,可通过产生乳酸、H2O2和其他抑制物质如嗜酸乳菌素,刺激免疫系统等方式来抑制大肠埃希菌、假丝酵母菌、阴道加德纳菌的过度生长,维持阴道微生态平衡。但乳杆菌的过量生长可造成阴道上皮鳞状细胞的破裂,导致一些类似外阴阴道假丝酵母菌病(VVC)的临床症状,即细胞溶解性阴道病(CV)。通过对CV的诊断、临床鉴别、治疗等方面进行文献回顾,提示本病发病率低于VVC、复发性VVC(RVVC)等,临床中易误诊误治。对于长期阴道分泌物异常、实验室真菌检查反复阴性、经验使用治疗真菌感染类药物无效的患者,应积极考虑本病的可能。
[Abstract]:Lactobacillus is an important member of female vaginal normal flora. It can inhibit Escherichia coli and Candida cerevisiae by producing H _ 2O _ 2 lactate and other inhibitors such as Lactobacillus acidophilus and stimulating immune system. The excessive growth of Gardnerella vaginalis maintains the microecological balance of vagina, but the excessive growth of Lactobacillus can cause the rupture of squamous cells of vaginal epithelium. Some clinical symptoms such as vulvovaginal Candida cerevisiae (VVC), I. e., Cytolytic vaginosis, were caused. Literature review on the diagnosis, clinical differentiation and treatment of CV was carried out. The results suggest that the incidence of this disease is lower than that of VVC and recurrent VVCn RVVC, and it is easy to be misdiagnosed and mistreated in clinic. The possibility of this disease should be actively considered in patients who experience ineffective treatment of fungal infection drugs.
【作者单位】：四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室;
【基金】：国家自然科学基金(编号:81572573)
【分类号】：R711.31
【正文快照】： 细胞溶解性阴道病(cytolytic vaginosis,CV)又称乳酸过度生长综合征、Doderlein's细胞溶解病,是指因阴道内微生态优势菌(主要指乳杆菌)过度增殖而导致阴道鳞状上皮细胞溶解破裂而引起相应临床症状的一种阴道疾病[1]。在世界范围内,目前此类研究文献不足20篇,造成临床医生对此

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