精液优化处理前后精子畸形率的变化及其对人工授精结局的影响

发布时间：2018-01-08 18:01

本文关键词：精液优化处理前后精子畸形率的变化及其对人工授精结局的影响　出处：《交通医学》2016年06期 　论文类型：期刊论文

【摘要】：目的 :比较精子畸形率在精液优化处理前后的变化及对IUI妊娠结局的影响。方法:选择进行IUI助孕患者精液优化处理前后采用Diff-Quik染色法检测精子畸形率,分析精子形态在优化处理前后的变化及其与IUI临床妊娠率的关系。结果:132个IUI治疗周期中精子畸形率高于正常值的有95个周期,精液优化处理前后平均正常形态精子率(2.69±1.75)%vs(3.62±2.50)%,平均精子畸形指数(SDI)1.32±0.15 vs 1.31±0.19,平均畸形精子指数(TZI)1.36±0.15 vs 1.36±0.19;精液优化处理后正常形态精子比率明显高于精液优化处理前(P0.05),精子畸形指数及畸形精子指数优化处理前后比较,差异无统计学意义(P0.05)。精液优化处理后正常形态精子率(normal morphology sperm rate,NMSR)仍未达标的72个治疗周期中,IUI临床妊娠12例,临床妊娠率16.67%;处理后精子正常形态率达标的60个治疗周期中,IUI临床妊娠7例,临床妊娠率11.67%,两组差异无统计学意义(P0.05)。结论:密度梯度离心法处理精液后可以显著降低精子畸形率,但密度梯度离心处理后精子畸形率的高低与IUI妊娠结局无明显相关性。
[Abstract]:Objective: to compare the changes of sperm malformation rate before and after semen optimization and its effect on pregnancy outcome of IUI. Sperm malformation rate was detected by Diff-Quik staining before and after optimal treatment of semen with IUI. The changes of sperm morphology before and after optimal treatment and the relationship between sperm morphology and clinical pregnancy rate of IUI were analyzed. Results: in 132 cycles of IUI treatment, the abnormal rate of sperm was higher than the normal value for 95 cycles. The average normal sperm rate before and after optimized semen treatment was 2.69 卤1.75 卤3.62 卤2.50%. The average sperm malformation index (SDI) was 1.32 卤0.15 vs 1.31 卤0.19. The mean sperm index of deformity was 1.36 卤0.15 vs 1.36 卤0.19; The percentage of normal sperm after optimized treatment was significantly higher than that of P0.05before the optimized treatment. The sperm deformity index and sperm deformity index were compared before and after the optimization treatment. There was no significant difference in normal morphology sperm rate. There were 12 cases of IUI pregnancy in 72 treatment cycles, and the clinical pregnancy rate was 16.67%. There were 7 cases of clinical pregnancy and 11.67% cases of clinical pregnancy in the 60 treatment cycles in which the normal morphology rate of spermatozoa was up to standard after treatment. There was no significant difference between the two groups (P 0.05). Conclusion: the sperm deformity rate can be significantly reduced by density gradient centrifugation. However, there was no significant correlation between sperm abnormality rate and pregnancy outcome of IUI after density gradient centrifugation.
【作者单位】：南通大学附属医院生殖医学中心;
【分类号】：R714.8
【正文快照】： 对于男性而言,产生足够数量的精子是使女方受孕的前提条件。目前,精液常规分析是男性生育功能评估一项重要参考依据,精子形态分析是精液常规分析中的一项重要指标。然而精子功能受损被认为是导致男性不育的主要原因[1],精子功能的受损往往与精子形态异常相关。有研究认为,精子

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