子宫颈癌中IQGAP1的表达及其意义

发布时间：2018-01-09 20:35

本文关键词：子宫颈癌中IQGAP1的表达及其意义　出处：《临床与实验病理学杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨子宫颈癌组织和癌旁组织中IQ结构域GTP酶激活蛋白1(IQ-domain GTPase-activating protein 1,IQGAP1)的表达及其意义。方法采用免疫组化SP法检测48例子宫颈癌组织和23例癌旁组织中IQGAP1的表达,并分析IQGAP1表达与子宫颈癌临床病理特征的关系。结果 IQGAP1在子宫颈癌中的阳性率为77.1%(37/48),明显高于癌旁组织(30.4%,7/23),两组相比差异有统计学意义(χ~2=14.285,P0.01)。IQGAP1表达与子宫颈癌组织分化程度(χ~2=3.102,P0.05)、临床分期(χ~2=7.111,P0.05)和淋巴结转移(χ~2=6.553,P0.05)相关;与患者年龄(χ~2=0.112,P0.05)无关。结论子宫颈癌组织中IQGAP1蛋白阳性率明显高于癌旁组织,且与肿瘤分化程度、临床分期及有无淋巴结转移密切相关,有望成为子宫颈癌生物学行为的有效指标之一。
[Abstract]:Objective to investigate the IQ domain GTP domain GTPase-activating protein 1 (IQ-domain GTPase-activating protein 1) in cervical carcinoma and paracancerous tissues. Methods Immunohistochemical SP method was used to detect the expression of IQGAP1 in 48 cases of cervical carcinoma and 23 cases of adjacent tissues. The relationship between the expression of IQGAP1 and the clinicopathological features of cervical cancer was analyzed. Results the positive rate of IQGAP1 in cervical carcinoma was 77.1 / 37 / 48). It was significantly higher than that in paracancerous tissue (30.4 / 23), and the difference between the two groups was statistically significant (蠂 ~ (2 + 2) ~ (14.285)). The expression of P0.01 and IQGAP1 was correlated with the degree of differentiation of cervical carcinoma (蠂 2 / 3.102 / P 0.05) and clinical stage (蠂 2 = 7.111). P0.05) and lymph node metastasis (蠂 2 + 6.553) were correlated with lymph node metastasis (P0.05). Conclusion the positive rate of IQGAP1 protein in cervical carcinoma is significantly higher than that in paracancerous tissues and is related to the degree of tumor differentiation. Clinical staging and lymph node metastasis are closely related, which is expected to be one of the effective indicators of biological behavior of cervical cancer.
【作者单位】：武汉市妇女儿童医疗保健中心检验部;武汉市妇女儿童医疗保健中心病理科;
【分类号】：R737.33
【正文快照】： 子宫颈癌是全球女性常见的恶性肿瘤之一,发病率和病死率一直居高不下[1]。研究表明,子宫颈癌的发生、发展是多基因、多步骤共同作用的结果,与细胞生长周期调节失衡、信号传导系统紊乱、癌基因和抑癌基因的表达异常等均存在密切关系[2-4]。IQ结构域GTP酶激活蛋白1(IQ-domain GT

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