地屈孕酮治疗先兆流产患者血清PIBF的表达分析

发布时间：2018-01-12 14:02

本文关键词：地屈孕酮治疗先兆流产患者血清PIBF的表达分析　出处：《热带医学杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨孕酮诱导的封闭因子(PIBF)与妊娠早期先兆流产的关系以及地屈孕酮的胚胎保护作用。方法黄体功能不全的先兆流产患者42例为实验组,给予地屈孕酮治疗2周;同期健康早期妊娠妇女40例为对照组。采用酶联免疫吸附方法(ELISA)检测两组孕妇血清PIBF、孕酮浓度并进行分析。结果两组孕妇的年龄、孕次和治疗前后妊娠时间比较差异无统计学意义(P0.05)。治疗前,实验组血清孕酮及PIBF水平低于对照组(P0.05);治疗后两者均呈上升趋势(P0.05),PIBF达到对照组水平(P0.05),孕酮低于对照组(P0.05)。对照组观察后血清PIBF水平呈明显上升趋势,孕酮小幅上升(P0.05)。观察前,对照组血清孕酮与PIBF之间呈正相关(P0.05);观察后,两变量间不存在相关性;无论在治疗前还是治疗后,实验组两变量间均不存在相关性(P0.05)。结论妊娠早期血清低水平的PIBF是引起先兆流产的因素之一。地屈孕酮的胚胎保护作用可能是通过上调血清PIBF表达水平来实现的。动态检测孕妇血清PIBF水平有助于先兆流产的临床诊断和地屈孕酮的疗效评估。
[Abstract]:Objective to investigate the relationship between progesterone-induced blocking factor (PIBF) and threatened abortion in early pregnancy and the protective effect of Diproprogesterone on embryo. Methods 42 patients with threatened abortion with luteal dysfunction were treated as experimental group. The patients were treated with diproprogesterone for 2 weeks. The serum PIBFand progesterone concentrations of 40 healthy early pregnant women in the same period were measured and analyzed by Elisa. Results the age of the two groups was analyzed. There was no significant difference between pregnant time and pregnancy time before and after treatment. Before treatment, the levels of serum progesterone and PIBF in the experimental group were lower than those in the control group (P 0.05). After treatment, both of them showed an increasing trend. P0.05 PIBF reached the level of control group (P0.05). Progesterone was lower than the control group (P 0.05). After observation, the serum PIBF level in the control group showed an obvious upward trend, and the progesterone increased slightly (P 0.05). There was a positive correlation between serum progesterone and PIBF in the control group (P 0.05). After observation, there was no correlation between the two variables. Before and after treatment. There was no correlation between the two variables in the experimental group (P0.05). Conclusion low serum level of PIBF in early pregnancy is one of the factors leading to threatened abortion. The embryonic protective effect of Diproprogesterone may be achieved by upregulating the expression of serum PIBF. The serum PIBF level is helpful to the clinical diagnosis of threatened abortion and the evaluation of the curative effect of Diproprogesterone.
【作者单位】：南京医科大学附属南京妇幼保健院妇女保健科;
【基金】：南京医科大学科技发展项目(2010NJMUZ14)
【分类号】：R714.21
【正文快照】： 妊娠被认为是一种半同种移植过程,母胎之间的相互作用是维持妊娠成功的主要原因。一定水平的孕酮对妊娠的维持至关重要,当黄体功能不足时,子宫内膜分泌反应不良、发育延迟,不利于受精卵的种植和胚胎发育及母胎界面免疫耐受的形成从而导致流产的发生。孕酮在妊娠8-10周以前主要

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