枸橼酸氯米芬联合二甲双胍对多囊卵巢综合征患者排卵效果及血管活性因子的影响

发布时间：2018-01-13 05:18

  本文关键词：枸橼酸氯米芬联合二甲双胍对多囊卵巢综合征患者排卵效果及血管活性因子的影响　出处：《医学综述》2016年21期 　论文类型：期刊论文

  更多相关文章： 多囊卵巢综合征 枸橼酸氯米芬 二甲双胍 血管活性因子

【摘要】：目的探讨枸橼酸氯米芬联合二甲双胍对多囊卵巢综合征(PCOS)患者排卵效果及血管活性因子的影响。方法将2011年7月至2014年7月深圳市宝安区人民医院收治的PCOS患者70例按照随机数字表法分为联合组和对照组,各35例。对照组口服枸橼酸氯米芬胶囊,1粒/d,共服用5 d;在对照组的基础上,联合组餐后0.5 h加用口服二甲双胍,0.5 g/次,3次/d,共服用4周。比较两组治疗后排卵情况,并检测两组治疗前和治疗1个月后性激素、血脂及血管活性因子水平。结果对照组治疗后睾酮(T)、胰岛素(INS)显著降低,联合组治疗后黄体生成素(LH)、LH/卵泡雌激素(FSH)、T、INS均较治疗前显著降低,差异有统计学意义(P0.05);其中治疗后联合组LH、LH/FSH、T、INS均显著低于对照组[(5.79±0.73)U/L比(9.98±1.47)U/L,(1.21±0.13)比(2.00±0.23),(1.41±0.20)nmol/L比(1.75±0.26)nmol/L,(19.87±6.72)U/L比(27.39±8.26)U/L],差异有统计学意义(P0.05)。治疗后两组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均较治疗前显著降低,高密度脂蛋白胆固醇(HDL-C)较治疗前显著升高,差异有统计学意义(P0.05);治疗后联合组TC、TG、LDL-C显著低于对照组[(3.45±0.31)mmol/L比(3.95±0.47)mmol/L,(1.12±0.17)mmol/L比(1.43±0.21)mmol/L,(2.28±0.42)mmol/L比(2.49±0.46)mmol/L],HDL-C显著高于对照组[(1.98±0.51)mmol/L比(1.62±0.24)mmol/L],差异有统计学意义(P0.05)。治疗后两组患者血清血管紧张素Ⅱ(AT-Ⅱ)、血管内皮生长因子(VEGF)均较治疗前显著降低,联合组血清AT-Ⅱ、VEGF水平显著低于对照组[(1.21±0.16)ng/L比(1.43±0.20)ng/L,(0.23±0.02)ng/L比(0.29±0.04)ng/L],差异有统计学意义(P0.05)。结论二甲双胍联合枸橼酸氯米芬能够调节PCOS患者血清性激素、血脂及血管活性因子水平,改善卵巢排卵功能,值得临床推广。
[Abstract]:Objective to investigate the clomiphene citrate combined with metformin on polycystic ovary syndrome (PCOS) patients and vasoactive factors affect ovulation effect. Methods from July 2011 to July 2014 in Baoan District people's Hospital of Shenzhen city from 70 PCOS patients were randomly divided into combined group and control group, each of 35 cases. Control group was treated with Clomifene Citrate Capsules, 1 /d, taking a total of 5 d; on the basis of the control group, combined group 0.5 h after meal with oral metformin, 0.5 g/, 3 /d, taking a total of 4 weeks. Ovulation after treatment between the two groups, and two groups were detected before treatment and after treatment for 1 months, sex hormone, blood lipid and the level of vasoactive factors. Results in the control group after treatment of testosterone (T), insulin (INS) decreased significantly, the combined treatment group after the luteinizing hormone (LH), LH/ (FSH), follicle stimulating hormone T, INS were significantly lower than those before treatment, the difference was statistically significant (P0.05); the 涓�娌荤枟鍚庤仈鍚堢粍LH,LH/FSH,T,INS鍧囨樉钁椾綆浜庡�圭収缁刐(5.79卤0.73)U/L姣，

本文编号：1417635