子痫前期患者血清胱抑素C检测的临床意义

发布时间：2018-01-14 08:29

本文关键词：子痫前期患者血清胱抑素C检测的临床意义　出处：《新疆医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨血清胱抑素C的变化对子痫前期的病情预测及与妊娠结局的关系。。方法：回顾式研究，分析汉族、维吾尔族正常晚期妊娠者各50例，汉族、维吾尔族子痫前期轻度患者分别52、49例，子痫前期重度患者分别45、40例，测定血清胱抑素C、尿素氮、肌酐，白蛋白，24小时尿蛋白，血压，比较子痫前期患者与正常对照组的胱抑素C水平差异，并对不同严重程度、不同妊娠结局的子痫前期患者的临床资料、不良妊娠结果（包括子痫、羊水过少、胎儿窒息、胎盘早剥、胎儿生长受限、HELLP综合征、子痫等）进行分析比较。结果：本研究共纳入人数286人，子痫前期患者186例，其中子痫前期患者轻度组101例，重度组85例，正常对照组孕妇100例。子痫前期患者的收缩压、胱抑素C水平均显著高于正常对照组，，差异有统计学意义（P0.05）；轻度组患者的收缩压、胱抑素C值均显著低于重度组,差异有统计学意义（P0.05）；汉族与维吾尔族子痫前期汉族胱抑素C差异无统计学意义（P0.05）；轻度组患者出现羊水过少、胎盘早剥、胎儿生长受限、HELLP综合征的人数均低于重度组，差异均具有统计学意义；结局不良组患者的胱抑素C水平高于良好组,差异有统计学意义（P0.05）。结论：子痫前期患者的血清胱抑素C水平明显上升，水平升高与严重程度相关，提示与不良妊娠结局有关。
[Abstract]:Objective: To investigate the changes of preeclampsia serum cystatin C in the prognosis and relationship with pregnancy outcome. Methods: retrospective study, analysis of the Han nationality, Uygur normal pregnancy in 50 cases, Han, Uygur patients with mild preeclampsia were 52,49 cases, patients with severe preeclampsia were 45,40 cases, serum cystatin C, urea nitrogen, creatinine, albumin, 24 hours urine protein, blood pressure difference, Cystatin C levels in patients with preeclampsia compared with normal control group, and the difference of the severity of the clinical data of different pregnancy outcomes in preeclampsia patients, adverse pregnancy outcomes (including eclampsia, oligohydramnios, fetal asphyxia, placental abruption, fetal growth limited, HELLP syndrome, eclampsia, etc.) were analyzed and compared. Results: the study included a total number of 286 people, 186 cases of patients with preeclampsia, including patients with mild preeclampsia group 101 cases, 85 in severe group Cases of normal pregnant women in the control group. 100 cases of preeclampsia patients with systolic blood pressure, serum cystatin C levels were significantly higher than the normal control group, the difference was statistically significant (P0.05); mild group, systolic blood pressure, serum cystatin C values were significantly lower than those in severe group, the difference was statistically significant (P0.05); no statistical significance of Han and Uygur Han preeclampsia cystatin C (P0.05); the difference of patients with mild oligohydramnios, placental abruption, fetal growth restriction, the number of HELLP syndrome were lower than that in severe group, the difference was statistically significant; adverse outcomes in patients with cystatin C level is higher than that of group, the difference was statistically significant (P0.05). Conclusion: eclampsia in patients with serum cystatin C levels increased obviously, elevated levels correlated with the severity of that associated with adverse pregnancy outcomes.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.244

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