ER、HNF-1β及COX-2在子宫内膜异位相关性卵巢癌中的表达及临床意义

发布时间：2018-01-15 09:45

本文关键词：ER、HNF-1β及COX-2在子宫内膜异位相关性卵巢癌中的表达及临床意义　出处：《重庆医学》2017年27期 　论文类型：期刊论文

【摘要】：目的探究雌激素受体(ER)、肝细胞核因子-1β(HNF-1β)以及环氧化酶-2(COX-2)在不同类型子宫内膜异位相关性卵巢癌(EAOC)中的表达差异。方法选取2011年7月至2016年4月苏州大学附属第二医院收治的EAOC患者44例,其中子宫内膜样癌17例,透明细胞癌21例,卵巢浆液性癌6例。采用免疫组织化学法检测ER、HNF-1β及COX-2在不同类型EAOC中的表达差异,并采用Spearman秩相关分析探讨三者表达水平的相关性。结果ER在子宫内膜样癌患者中的阳性率为100.0%,显著高于透明细胞癌患者的9.5%和卵巢浆液性癌患者的0%(χ~2=4.305,P0.01),而HNF-1β在透明细胞癌和卵巢浆液性癌患者中的阳性率分别为85.7%和100.0%,显著高于子宫内膜样癌患者的11.8%(χ~2=3.585,P0.01),COX-2在子宫内膜样癌、透明细胞癌和卵巢浆液性癌患者中的阳性率分别76.5%、81.0%、83.3%,差异无统计学意义(χ~2=0.744,P=0.104)。ER和HNF-1β的表达水平呈负相关(r=-0.428,P0.01),与COX-2的表达水平呈正相关(r=0.204,P=0.013)。结论 ER主要在子宫内膜样癌中表达,HNF-1β主要在透明细胞癌和卵巢浆液性癌中表达,ER的表达水平与HNF-1β及COX-2的表达水平具有一定的相关性。
[Abstract]:Objective to explore the estrogen receptor (ER). Hepatic nuclear factor-1 尾 (HNF-1 尾) and cyclooxygenase-2 (COX-2) in different types of endometriosis associated ovarian carcinoma (EAOC). Methods from July 2011 to April 2016, 44 patients with EAOC were treated in the second affiliated Hospital of Suzhou University. There were 17 cases of endometrial carcinoma, 21 cases of clear cell carcinoma and 6 cases of ovarian serous carcinoma. The expression of HNF-1 尾 and COX-2 in different types of EAOC was different. Spearman rank correlation analysis was used to investigate the correlation of the three expression levels. Results the positive rate of ER in endometrial carcinoma was 100.0%. It was significantly higher than that in patients with clear cell carcinoma (9.5%) and ovarian serous carcinoma (0%) (蠂 ~ 2 + 4.305 (P 0.01)). The positive rates of HNF-1 尾 in clear cell carcinoma and ovarian serous carcinoma were 85.7% and 100.0%, respectively. The number of COX-2 in endometrial carcinoma was significantly higher than that in endometrial carcinoma (蠂 ~ 2 = 3.585). The positive rates of clear cell carcinoma and ovarian serous carcinoma were 76.51.01 and 83.3, respectively. The difference was not statistically significant (蠂 ~ 2, 0.74, P < 0.05). There was a negative correlation between the expression level of HNF-1 尾 and the expression level of P ~ (0.104), P ~ (0.01), and a positive correlation was found between the expression level of COX-2 and the expression level of COX-2. Conclusion ER is mainly expressed in endometrial carcinoma and mainly in clear cell carcinoma and ovarian serous carcinoma. The expression of ER was correlated with the expression of HNF-1 尾 and COX-2.
【作者单位】：苏州大学附属第二医院妇产科;
【基金】：江苏省科技计划项目(BK2012599)
【分类号】：R737.31
【正文快照】： 子宫内膜异位症(endometriosis,EM)是以月经异常、痛经、不孕等为主要症状的妇科疾病,在临床上较为常见。有研究显示EM在妇女中的发病率为5%~20%[1]。虽然EM为良性疾病,但也具有一些与肿瘤类似的生物学特性,如侵袭性和对正常组织的损伤性,且已有研究表明,EM与卵巢癌发生、发展

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