血清和肽素、sFlt-1及AVP在子痫前期患者中的水平变化及其相关性

发布时间：2018-01-15 18:25

本文关键词：血清和肽素、sFlt-1及AVP在子痫前期患者中的水平变化及其相关性　出处：《山东医药》2017年13期 　论文类型：期刊论文

【摘要】：目的探讨血清和肽素(CPT)、可溶性血管内皮生长因子受体1(sFlt-1)、精氨酸加压素(AVP)在子痫前期(PE)患者中的水平变化及其相关性。方法收集妊娠期高血压患者(HT组)11例,早发型PE患者(E-PE组)12例,晚发型PE患者(L-PE组)27例。选择同期在本院正常产检并分娩的60例健康孕妇作为对照组,其中晚期妊娠患者(L-NT组)40例、早期妊娠患者(E-NT组)20例。采用ELISA法检测各组血清中CPT、sFlt-1、AVP水平,分析血清CPT水平与sFlt-1、AVP、年龄、收缩压、舒张压、胎儿体质量、发病孕周的相关性。结果 E-PE组、L-PE组间的取样孕周均小于L-NT组,且E-PE组的取样孕周小于L-PE组,差异有统计学意义(P均0.05);但E-NT组的取样孕周与E-PE组的取样孕周比较,P0.05;HT组、E-PE组及L-PE组血清中CPT、sFlt-1、AVP水平均高于LNT组(P均0.05);E-PE组血清中CPT、sFlt-1、AVP水平高于E-NT组(P均0.05);血清CPT与sFlt-1、AVP、年龄、SBP、DBP均呈正相关(r分别为0.064、0.330、0.001、0.346、0.673、0.622,P均0.01),而与胎儿体质量和发病孕周呈负相关(r分别为-0.423、-0.375,P均0.01)。结论 PE患者血清中CPT、sFlt-1、AVP水平升高,血清CPT与AVP、sFlt-1呈正相关。
[Abstract]:Objective to investigate the expression of soluble vascular endothelial growth factor receptor (VEGFR) in serum and peptide (CPT). The level of arginine vasopressin (AVP) in patients with preeclampsia (PEI) and its correlation. Methods 11 cases of hypertensive disorder complicating pregnancy were collected. There were 12 cases of early type PE and 27 cases of late type PE. 60 healthy pregnant women who had normal delivery and normal delivery in our hospital were selected as control group. There were 40 cases of L-NT in late pregnancy group and 20 cases of E-NT group in early pregnancy. The serum levels of CPTsFlt-1AVP in each group were detected by ELISA method. To analyze the correlation between serum CPT level and sFlt-1 AVP, age, systolic blood pressure, diastolic blood pressure, fetal body mass and gestational age. The gestational weeks of L-PE group were smaller than that of L-NT group, and the gestational weeks of E-PE group were smaller than L-PE group (P < 0.05). But the sampling gestational weeks in E-NT group were compared with those in E-PE group (P 0.05). The levels of serum CPTsFlt-1AVP in HT group and L-PE group were higher than those in LNT group (P < 0.05). The serum levels of CPTsFlt-1 AVP in E-PE group were higher than those in E-NT group (P 0.05). There was a positive correlation between serum CPT and sFlt-1 AVP, age SBP, DBP (r = 0.064 0. 330 0. 001 + 0. 344 卤0. 673, P < 0. 05). 0.622 P was 0. 01%, but negatively correlated with fetal body mass and gestational week, r = -0.423 ~ 0.375, respectively. Conclusion the level of serum CPTT sFlt-1AVP in PE patients is higher than that in PE patients, and there is a positive correlation between serum CPT and AVPsFlt-1.
【作者单位】：南方医科大学附属深圳市妇幼保健院;南方医科大学第一临床医学院;南方医科大学深圳医院;
【分类号】：R714.244
【正文快照】： 第一临床医学院;3南方医科大学深圳医院)子痫前期(PE)是妊娠期特有疾病,发病率为3.0%~8.4%,孕产妇病死率为9%~25%,是全球范围内严重影响母儿健康的疾病[1]。根据在妊娠34周前后是否发病,PE被分为早发型PE和晚发型PE。现一致认为早发型PE与胎盘功能障碍相关,病情明显更为严重,

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