卡前列素氨丁三醇应用时机对中央性前置胎盘剖宫产妇产后出血及血流动力学的影响

发布时间：2018-01-16 01:03

本文关键词：卡前列素氨丁三醇应用时机对中央性前置胎盘剖宫产妇产后出血及血流动力学的影响　出处：《中国药房》2017年11期 　论文类型：期刊论文

【摘要】：目的:探讨卡前列素氨丁三醇应用时机对中央性前置胎盘剖宫产妇产后出血及血流动力学的影响,并评价其安全性。方法:选取2015年1-12月我院住院分娩的中央性前置胎盘产妇138例,采用随机数字表法分为观察组和对照组,各69例。两组产妇均行剖宫产术,对照组产妇胎盘娩出后子宫体注射卡前列素氨丁三醇注射液250μg,观察组产妇断脐后立即宫底注射卡前列素氨丁三醇250μg。观察两组产妇手术时间、术中及术后出血量,并比较两组产妇术前及术后24 h血流动力学指标、凝血功能,以及不良反应发生情况。结果:观察组产妇手术时间显著短于对照组,术中出血量及24 h总出血量显著少于对照组,差异均有统计学意义(P0.05)。术前,两组产妇血流动力学指标和凝血功能指标比较,差异均无统计学意义(P0.05);术后24 h,两组产妇收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、纤维蛋白原(FIB)、D-二聚体(D-D)显著降低,心率(HR)显著升高,且观察组显著优于对照组,差异均有统计学意义(P0.05);两组产妇不良反应发生率比较(15.94%vs.13.04%),差异无统计学意义(P0.05)。结论:卡前列素氨丁三醇断脐后宫底注射有助于缩短中央性前置胎盘剖宫产手术时间,减少术中出血量,维持血流动力学指标相对稳定,改善凝血功能,且安全性较好。
[Abstract]:Objective: to investigate the effect of the application of carprostin-aminobutanol on hemorrhage and hemodynamics of central placenta previa after cesarean section. Methods: 138 pregnant women with central placenta previa from 2015 to December in our hospital were selected and randomly divided into observation group and control group. 69 cases in each group underwent cesarean section, and the control group received 250 渭 g carprostin-aminobutanol injection after placenta delivery. Carprostatin aminobutanol 250 渭 g was injected into the intrauterine floor immediately after umbilical cord rupture in the observation group. The operative time, intraoperative and postoperative blood loss were observed in the two groups. The hemodynamic indexes, coagulation function and adverse reactions were compared between the two groups before and 24 hours after operation. Results: the operative time of the observation group was significantly shorter than that of the control group. The intraoperative bleeding volume and 24 h total bleeding volume were significantly lower than those in the control group (P 0.05). Before operation, the hemodynamic indexes and coagulation function indexes of the two groups were compared. The difference was not statistically significant (P 0.05). 24 hours after operation, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (map) and fibrinogen fibrinogen (FIBN) D- dimer (D-D) were significantly decreased in both groups. Heart rate (HRV) increased significantly, and the observation group was significantly better than the control group, the difference was statistically significant (P 0.05). The incidence of adverse reactions in the two groups was 15.94 vs 13.04). Conclusion: intrauterine injection of carprostatin aminobutanol can shorten the time of cesarean section and reduce the amount of intraoperative bleeding in central placenta previa. The hemodynamic indexes were maintained relatively stable, the coagulation function was improved, and the safety was good.
【作者单位】：南阳市中心医院普外科;南阳市中心医院妇产科;
【分类号】：R719.8
【正文快照】： *护师。研究方向:普外科学。电话:0377-63200093。E-mail:heqingsen919@sina.com473000)中央性前置胎盘是指胎盘附着于下段子宫甚至子宫内口,可引起出血及早产,增加胎儿宫内窘迫风险;因下段子宫肌层收缩力较弱,胎儿娩出后,附着于子宫下段肌层的胎盘极易发生剥离不全,可能导致

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