宫颈鳞状细胞癌中YAP和CyclinD1的表达及其临床意义

发布时间：2018-01-16 07:24

本文关键词：宫颈鳞状细胞癌中YAP和CyclinD1的表达及其临床意义　出处：《中国妇产科临床杂志》2015年06期 　论文类型：期刊论文

【摘要】：目的探讨Yes相关蛋白(YAP)和细胞周期蛋白D1(CyclinD1)在宫颈上皮内瘤变(CIN)及宫颈鳞状细胞癌(CSCC)中的表达及与CSCC临床病理因素间的关系。方法应用免疫组织化学SP法及RTPCR分别检测105例CSCC、43例CIN和22例正常宫颈组织中YAP和CyclinD1蛋白和mRNA的表达水平。结果 YAP在正常宫颈、CIN和CSCC组织中的阳性表达率分别为22.72%、65.12%和89.52%,三组比较,差异有统计学意义(P0.05);CyclinD1在正常宫颈、CIN和CSCC组织中的阳性表达率分别为0、11.63%和65.71%,三组比较,差异有统计学意义(P0.05);YAP和CyclinD1在CSCC中的表达呈正相关(r=0.215,P0.05)。结论 YAP和CyclinD1的高表达可能与CSCC的发生发展有关,二者有望成为诊断、治疗CSCC的新靶点。
[Abstract]:Objective to investigate the role of Yes associated protein (YAP) and cyclin D1 (cyclin D1) in cervical intraepithelial neoplasia (cin) and cervical squamous cell carcinoma (CSCC). Methods Immunohistochemical SP method and RTPCR were used to detect CSCC in 105 cases. Expression of YAP and CyclinD1 protein and mRNA in 43 cases of CIN and 22 cases of normal cervix. Results YAP was expressed in normal cervix. The positive expression rates of CIN and CSCC were 65.12% and 89.52% in CIN and CSCC, respectively. The difference among the three groups was statistically significant (P 0.05). The positive expression rates of CyclinD1 in cin and CSCC of normal cervix were 11.63% and 65.71%, respectively. The difference was statistically significant (P 0.05). There was a positive correlation between the expression of YAP and CyclinD1 in CSCC. Conclusion the high expression of YAP and CyclinD1 may be related to the occurrence and development of CSCC, which may be a new target for diagnosis and treatment of CSCC.
【作者单位】：山东省滕州市妇幼保健院妇产科;山东省滕州市中心人民医院病理科;
【分类号】：R737.33
【正文快照】： 宫颈癌是常见的生殖道恶性肿瘤,严重威胁着女性的生命健康。有研究表明,宫颈癌是多步骤、多基因共同作用的结果,与细胞生长周期调节失衡、信号传导系统紊乱、癌基因和抑癌基因的表达异常存在密切关系[1-2]。Hippo通路是近年来新发现的信号通路,其在维持器官大小、调控细胞增殖

【共引文献】