中药与来曲唑在肾虚血瘀型排卵障碍性不孕症患者中的联合应用

发布时间：2018-01-17 00:27

本文关键词：中药与来曲唑在肾虚血瘀型排卵障碍性不孕症患者中的联合应用　出处：《中国实验方剂学杂志》2015年13期 　论文类型：期刊论文

【摘要】：目的:探讨中药周期疗法与来曲唑在肾虚血瘀型排卵障碍性不孕症患者中的联合应用价值。方法:将92例肾虚血瘀型排卵障碍性不孕症患者随机按数字表分为治疗组和对照组各46例,对照组患者采用来曲唑的临床药物治疗,治疗组患者则在对照组治疗的基础上加用中药周期疗法的联合治疗方案,并分别对两组患者的临床治疗情况及血清睾酮(T),雌二醇(E2),黄体生成素(LH),卵泡刺激素(FSH)的含量进行比较和分析。结果:与对照组相比,研究组的痊愈率50.00%(23/46),总有效率91.30%(42/46)均显著提升;研究组治疗后的主卵泡直径(19.89±3.25)mm,子宫内膜厚度(9.72±1.86)mm均明显增加;研究组的排卵率76.09%,妊娠率45.65%,活胎率90.48%均明显提高,而流产率9.52%则明显降低;研究组治疗后的E2(240.26±58.72)pmol·L-1,FSH(16.23±4.25)U·L-1水平均明显提高,而T(1.69±0.30)nmol·L-1,LH(24.35±6.18)U·L-1,LH/FSH(1.51±0.73)水平则明显降低;研究组治疗后的中医证候积分(5.36±1.20)分明显将低;研究组中医证候疗效达到临床痊愈标准的比率54.35%(25/46)明显提高,总有效率95.65%(44/46)显著改善,差别均具有统计学意义(P0.05)。结论:中药周期疗法联合来曲唑对于肾虚血瘀型排卵障碍性不孕症相关临床症状的改善以及临床治疗效果的提升均具有积极的促进作用,可作为肾虚血瘀型排卵障碍性不孕症临床治疗的理想方案予以推广。
[Abstract]:Objective: to explore the combined application value of periodic therapy of traditional Chinese medicine and letrozole in infertile patients with ovulation disorder of kidney deficiency and blood stasis type. Ninety-two patients with ovulatory disorders of kidney deficiency and blood stasis type were randomly divided into treatment group (n = 46) and control group (n = 46). The patients in the control group were treated with letrozole and the patients in the treatment group were treated with the combination of Chinese medicine cycle therapy on the basis of the treatment of the control group. The clinical treatment and serum testosterone, estradiol E _ (2) and luteinizing hormone (LH) of the two groups were also studied. Results: compared with the control group, the recovery rate of the study group was 50.00-23 / 46). The total effective rate of 91.30g / 42 / 46) was significantly increased. The diameter of main follicle and endometrial thickness were 19.89 卤3.25mm and 9.72 卤1.86mm, respectively. In the study group, the ovulation rate was 76.09, the pregnancy rate was 45.65, the live fetus rate was 90.48%, and the abortion rate was 9.52%. In the study group, the levels of E2V 240.26 卤58.72 pmol 路L -1 FSHN 16.23 卤4.25 U 路L -1 were significantly increased after treatment. However, the level of TX 1.69 卤0.30nmol 路L -1 LHN 24.35 卤6.18 U 路L -1 LH / FSH 1.51 卤0.73) decreased significantly. After treatment, the score of TCM syndromes in the study group was 5.36 卤1.20, and the score was significantly lower than that in the control group. In the study group, the rate of curative effect of TCM syndromes up to the standard of clinical cure was 54.35% / 46) and the total effective rate was 95.65% / 44% (46%). The difference was statistically significant (P0.05). Conclusion: Chinese medicine cycle therapy combined with letrozole has a positive effect on the improvement of clinical symptoms and the improvement of clinical treatment effect of ovulatory disorder of kidney deficiency and blood stasis type. It can be popularized as an ideal treatment for ovulatory infertility with kidney deficiency and blood stasis.
【作者单位】：华中科技大学同济医学院附属武汉市普爱医院;湖北省妇幼保健院;
【基金】：2004年武汉市卫生局基金项目(武卫[2004]241)
【分类号】：R711.6
【正文快照】： 近年来我国女性的排卵障碍性不孕人数逐年增多,排卵障碍导致不孕的发生率由20%上升至现在的40%。目前,不孕症已成为全球医学界广泛关注和研究的热点与难点,不孕症往往是指患者存在正常性生活,并且在未经避孕的前提下一年未发生妊娠[1]。据不完全统计,我国每年大约有10%~15%的

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