GnRH拮抗剂方案中HCG扳机时机对胚胎的影响

发布时间：2018-01-17 15:07

  本文关键词：GnRH拮抗剂方案中HCG扳机时机对胚胎的影响　出处：《现代妇产科进展》2017年03期 　论文类型：期刊论文

  更多相关文章： GnRH拮抗剂 HCG扳机时机 超促排卵 体外受精-胚胎移植

【摘要】：目的:探讨促性腺激素释放激素拮抗剂(GnRH antagonist)方案超促排卵过程中推迟人绒毛膜促性腺激素(HCG)扳机时机对胚胎质量及妊娠率等的影响。方法:回顾性分析2015年1月至12月在我院接受体外受精-胚胎移植(IVF-ET)助孕的不孕症患者183例,均采用GnRH拮抗剂促排方案,于月经周期第2天启用促性腺激素(Gn),当有卵泡平均直径达到14mm,加用GnRH拮抗剂。按照传统HCG扳机时机(有3个≥17mm卵泡)与推迟1天扳机分为2组:早期HCG组(149例)和晚期HCG组(34例),比较两组数据。结果:HCG扳机日,晚期HCG组≥15mm的卵泡数明显多于早期HCG组(P=0.026)。晚期HCG组Gn使用天数及Gn使用总量均明显高于早期HCG组(P=0.000,P=0.012)。妊娠结局方面,晚期HCG组较早期HCG组具有更高的妊娠率(76.00%vs 50.45%,P=0.020)。两组受精率、继续妊娠率、流产率、异位妊娠率均无显著差异(P0.05)。结论:GnRH拮抗剂促排方案中,适当推迟HCG扳机时间不影响胚胎质量和妊娠率,可以推行。
[Abstract]:Objective: to investigate the delay of human chorionic gonadotropin (HCG) during hyperstimulation of ovulation by gonadotropin releasing hormone antagonist (GnRH antagonistist). Effects of trigger timing on embryo quality and pregnancy rate. Methods: IVF-ETs received in our hospital from January 2015 to December were retrospectively analyzed. 183 cases of infertility assisted pregnancy. The gonadotropin gonadotropin was used on the second day of menstrual cycle, and the mean diameter of follicles was 14mm. According to the traditional HCG trigger timing (3 鈮，

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