卵母细胞滑面内质网聚集的研究进展

发布时间：2018-01-18 02:24

本文关键词：卵母细胞滑面内质网聚集的研究进展　出处：《中华生殖与避孕杂志》2017年06期 　论文类型：期刊论文

【摘要】：在人类辅助生殖中,经促排卵体外获得的卵母细胞中,有滑面内质网聚集(smooth endoplasmic reticulum aggregate,SERa)形成者占有一定比例。既往研究显示,SERa对胚胎质量及妊娠结局会造成不良影响。但近年来研究显示:SERa卵母细胞可诞生完全健康的新生儿。卵母细胞胞质内SERa的形成可能与遗传因素、卵巢过度刺激、超促排卵方案及扳机日高雌二醇(E2)等多种因素相关。大多数学者认为卵母细胞SERa的形成会导致受精率、卵裂率和囊胚形成率降低及胚胎质量的下降,使得妊娠率显著降低;然而,也有多项报道已证实SERa的卵母细胞的胚胎质量与正常卵母细胞并无差异。因此对于那些临床助孕治疗中获得SERa胚胎或者胚胎数目不足的患者,可考虑移植SERa胚胎。未来,应多关注SERa对体外受精(IVF)结局的影响及着重阐明SERa形成机制,从而从根本上防止异常卵母细胞的出现。
[Abstract]:In human assisted reproduction, oocytes obtained by ovulation stimulation in vitro. The formation of smooth endoplasmic reticulum aggregates (SERaA) with smooth endoplasmic reticulum (ER) was found in a certain proportion. SERa can have adverse effects on embryo quality and pregnancy outcome. However, recent studies have shown that:. SERa oocytes can produce healthy newborns. The formation of SERa in oocyte cytoplasm may be associated with genetic factors. Many factors are related to ovarian hyperstimulation, hyperstimulation and E2). Most scholars believe that the formation of oocyte SERa may lead to fertilization rate. The cleavage rate, blastocyst formation rate and embryo quality decreased significantly. But... It has also been reported that the quality of SERa oocytes is not different from that of normal oocytes. Therefore, for those who receive SERa embryos or have insufficient number of embryos in clinical pregnancy assistance therapy. In the future, more attention should be paid to the effect of SERa on the outcome of IVF and to clarify the mechanism of SERa formation so as to prevent the appearance of abnormal oocytes.
【作者单位】：中山大学附属第六医院生殖医学研究中心;
【分类号】：R714.8
【正文快照】： 自从1978年第一例试管婴儿诞生以来,辅助生殖技术在近40年间获得了长足的进步,人们对人类生殖现象的研究达到了前所未有的高度。尽管如此,生殖过程中的一些异常现象仍未得到清晰的阐释,卵母细胞滑面内质网聚集(SERa)便是其中之一。人们对SERa卵母细胞的看法,在丢弃与利用之间

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