母血清中孕三联生化标记物联合超声筛查出生缺陷分析

发布时间：2018-01-18 14:43

本文关键词：母血清中孕三联生化标记物联合超声筛查出生缺陷分析　出处：《福建医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的:分析大田县4789例孕中期孕妇产前检查情况，为提高基层医疗单位产前筛查质量提出建议。方法:对孕中期(15～206周)4652例单胎孕妇进行甲胎蛋白(AFP)和游离一β-h C G (free—β-H C G)、游离雌三醇（uE3）的血清生化指标检测，利用lifecycle3.1型号产前筛查的软件，对可能影响检测结果的部分因素，如年龄、体重，孕周等加以分析校正，，分析出生缺陷的风险；另外，137例大于35岁者于18-236周直接行产前诊断。所有病例结合系统超声检查进行出生缺陷分析。结果:（1）血清学高风险检出率：4789例孕妇中4652例进行血清学筛查，检出高风险195例，总的高风险发生率4.19%；21-三体综合征高风险（即唐氏综合征，DS）181例，唐氏综合征（DS）高风险发生率3.89%；神经管畸形（NTD）阳性14例，阳性发生率0.30%；本资料未发现18三体综合征高分险孕妇；（2）彩超检查出不同程度畸形、死胎者共56例：其中血清学高风险病例中15例，血清低风险病例中41例。（3）羊水细胞染色体诊断：181例DS高风险孕妇中有141例到三明市第一医院产前诊断中心进行了羊水细胞染色体检查，确诊唐氏儿2例（核型47，XN，+21），其余的未发现染色体核型异常。结论:在基层医院和产前诊断中心配合下，对孕妇孕中期血清学筛查联合超声检查，可有效降低出生缺陷儿的出生率。
[Abstract]:Objective : To analyze the prenatal check of 4789 pregnant women in Datian county , and to make recommendations for improving the quality of prenatal screening of medical units at the grass - roots level . Methods : The serum biochemical indexes of AFP and free - 尾 - h C - G and uE3 were detected in 4652 pregnant women in the middle of pregnancy ( 15 - 206 weeks ) . The risk of birth defects was analyzed by using the software of prenatal screening , such as age , body weight and gestational week . Results : ( 1 ) High - risk serologic high - risk rate : Of the 4789 pregnant women , 4652 were serologically screened , 195 cases were high - risk , the overall high - risk incidence was 4.19 % ; the high - risk rate of 21 - three - body syndrome ( DS ) 181 cases , Down syndrome ( DS ) high - risk incidence was 3.89 % ; Conclusion : Under the cooperation of primary hospital and prenatal diagnosis center , it can effectively reduce the birth rate of birth defects .

【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.5

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