miRNA与子宫内膜癌发生发展预后相关性的研究进展

发布时间：2018-01-19 05:16

  本文关键词： miRNA 子宫内膜癌 发生发展 转移 耐药　出处：《中国妇产科临床杂志》2015年01期 　论文类型：期刊论文

【摘要】：miRNA(microRNA)是一类内源性的非编码单链小分子RNA,随着近年来对其研究的不断深入,发现miRNA与特定基因的沉默或/和保护某些基因组免受外源性干扰等密切相关。miRNA通过与靶mRNA特异性结合使其降解、干扰翻译,参与生物体的增殖、分化和凋亡等生命活动。miRNA在多种肿瘤中都存在表达异常,提示其在肿瘤的发生发展中扮演着重要的角色。子宫内膜癌(endometrial cancer,EC)是妇科三大恶性肿瘤之一,发病机制尚未明确,越来越多的学者们开始关注miRNA表达谱的异常与子宫内膜癌的发生、发展、临床治疗等的相关性,本文就miRNA在子宫内膜癌中的研究进展做一综述。
[Abstract]:MiRNAs microRNAs (miRNAs) are a class of endogenous non-coding single-stranded small RNAs, which have been studied in recent years. It is found that miRNA is closely related to the silencing of specific genes and / or the protection of certain genomes from exogenous interference. MiRNAs are specifically combined with target mRNA to degrade them and interfere with translation. The expression of miRNA is abnormal in many kinds of tumors, such as proliferation, differentiation and apoptosis. It is suggested that endometrial carcinoma is one of the three major gynecological malignancies, and its pathogenesis is not clear. More and more scholars begin to pay attention to the correlation between abnormal miRNA expression profile and the occurrence, development, clinical treatment of endometrial carcinoma. This article reviews the research progress of miRNA in endometrial carcinoma.
【作者单位】： 福建医科大学附属协和临床医学院;福建省妇幼保健院;福建医科大学附属协和医院妇产科;
【分类号】：R737.33
【正文快照】： 子宫内膜癌是女性生殖道三大恶性肿瘤之一,近年来发病率有上升的趋势,居女性患癌排名的第4位,仅次于乳腺癌、肺癌和大肠癌[1],尽快明确其发病机制是达到治疗目的的根本途径。目前认为多数的EC与长期暴露于无抵抗的雌激素相关,但并非所有类型子宫内膜癌都是激素依赖性,近年来研，

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