超短方案在高龄体外受精患者中的应用

发布时间：2018-01-19 14:16

本文关键词： 体外受精-胚胎移植(IVF-ET) 高龄超短方案微刺激方案累积妊娠率累积活产率　出处：《中华生殖与避孕杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨超短方案在高龄患者进行体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)中的疗效。方法回顾性分析326例年龄38岁女性的IVF-ET周期的临床资料,根据不同促排卵方案分为超短方案组和微刺激方案组。比较和分析2种促排卵方案的疗效。结果超短方案组的获卵数(5.8±0.3)、正常受精数(3.5±0.2)、优质胚胎数(2.5±1.8)和有效胚胎数(2.6±0.2)均高于微刺激方案组(2.4±0.1,1.5±0.1,1.0±1.0,1.7±0.1)(P0.001);患者的卵裂率和优质胚胎率组间无统计学差异(P0.05)。但超短方案组每取卵周期累积妊娠率(40.00%)和累积活产率(8.41%)均高于微刺激方案组(30.00%,7.52%)(P0.001),新鲜胚胎移植取消率(47.00%)明显低于微刺激方案组(99.56%)(P0.001)。结论对于高龄IVF患者进行促排卵时使用超短方案,可以获得更多的卵母细胞和有效胚胎,增加每取卵周期的累积妊娠率和活产率,并且通过降低新鲜胚胎移植取消率,减少患者的心理负担,对于高龄IVF患者是一种比较好的选择。
[Abstract]:Objective to investigate the short scheme in vitro fertilization - embryo transplantation in the elderly patients (in vitro, fertilization-embryo transfer, IVF-ET) in curative effect. Methods Retrospective analysis of the clinical data of 326 cases of 38 year old female IVF-ET cycle, according to the different ovulation scheme is divided into short case group and micro stimulus group. Comparison and analysis of 2 ovulation induction effect. Results the number of oocytes ultra short group (5.8 + 0.3), the number of normal fertilization (3.5 + 0.2), the number of high-quality embryos (2.5 + 1.8) and the number of embryos (2.6 + 0.2) were higher than that of the micro stimulus group (2.4 + 0.1,1.5 + 0.1,1.0 + 1.0,1.7 + (0.1) P0.001); no significant difference in cleavage rate and high-quality embryo rate between the groups (P0.05). But each group ultrashort oocyte retrieval cycle cumulative pregnancy rate (40%) and the cumulative live birth rate (8.41%) was higher than that of the micro stimulus group (30%, 7.52%) (P0.001), the removal rate of fresh embryo transplantation (47%) Micro stimulus was significantly lower than that of group (99.56%) (P0.001). Conclusion for elderly IVF patients with ovulation using ultra short program, can obtain more effective oocytes and embryos, the cumulative increase in each oocyte retrieval cycle pregnancy rate and live birth rate, and by reducing the fresh embryo transfer cancellation rate, reduce the patient's psychological the burden for elderly patients with IVF is a good choice.

【作者单位】：上海交通大学医学院附属仁济医院生殖医学中心上海市辅助生殖与优生重点实验室;
【基金】：国家自然科学基金项目(81370687)~~
【分类号】：R714.8
【正文快照】： 反映女性生殖能力的卵巢储备功能与卵母细胞的数量相关,卵母细胞的数量和质量随着年龄的增长而逐渐下降。合适的促排卵方案是体外受精-胚胎移植(IVF-ET)成功的先决条件。不同的促排卵方案旨在安全地诱导多卵泡发育,增加可用胚胎数量,从而提升每一取卵周期内的临床妊娠率。随着

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