脆性组氨酸三联体蛋白在子宫内膜异位症中的表达

发布时间：2018-01-19 16:08

  本文关键词： 子宫内膜异位症 脆性组氨酸三联体 免疫组化　出处：《实用医学杂志》2015年16期 　论文类型：期刊论文

【摘要】：目的:观察脆性组氨酸三联体(FHIT)蛋白在子宫内膜异位症(EMT)中的表达及意义。方法:应用免疫组化SP法检测FHIT在28例EMT患者(EMT组)的在位内膜、异位内膜及28例单纯子宫肌瘤患者(对照组)子宫内膜中的表达情况。结果:FHIT主要表达在子宫内膜腺体上皮细胞的胞浆和胞膜中。FHIT在EMT患者的在位内膜和异位内膜的阳性率分别为68%(19/28)和54%(15/28),两者相比差异无统计学意义(P0.05);但均低于对照组的96%(27/28),差异有统计学意义(P0.05);EMT不同re-AFS分期的异位子宫内膜中,FHIT的表达情况不同,Ⅰ~Ⅱ期的阳性率较Ⅲ~Ⅳ期的阳性率明显升高,差异有统计学意义(P0.05)。结论 :FHIT可能与EMT的发病有关,并对疾病的严重程度有一定的影响。
[Abstract]:Objective: to observe the expression and significance of fragile histidine triad FHITprotein in endometriosis. Methods: immunohistochemical SP method was used to detect FHIT in 28 patients with EMT. The eutopic intima of EMT group. Ectopic endometrium and 28 patients with simple uterine leiomyoma (control group). Expression in endometrium. Results:. The positive rates of FHIT mainly expressed in cytoplasm and membrane of endometrial glandular epithelial cells were 68% in eutopic endometrium and ectopic endometrium in EMT patients. 19 / 28) and 54 / 15 / 28). There was no significant difference between the two groups (P 0.05). But it was significantly lower than that of the control group (96 / 27 / 28), and the difference was statistically significant (P 0.05). The expression of FHIT in ectopic endometrium with different re-AFS stages of EMT was different. The positive rate of FHIT in stage 鈪，

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