先证妊娠期糖尿病的正常糖耐量妇女的血糖波动变化

发布时间：2018-01-21 23:04

本文关键词： 血糖波动正常糖耐量妊娠期糖尿病　出处：《南京医科大学学报(自然科学版)》2015年11期 　论文类型：期刊论文

【摘要】：目的:分析先证妊娠期糖尿病(gestational diabetes mellitus,GDM)的正常糖耐量妇女的血糖波动变化特点。方法:南通大学第二附属医院就诊的GDM妇女在产后1年内进行75 g口服葡萄糖耐量试验,选择61例正常糖耐量妇女(空腹血糖5.6 mmol/L,糖负荷2 h7.8 mmol/L)纳入研究组(PGDM组)。同时选择61例年龄匹配的无GDM病史的正常糖耐量妇女为对照组(NC组)。所有对象均进行连续72 h动态血糖监测,并计算血糖波动参数,包括血糖标准差、平均血糖、平均血糖绝对差、平均血糖波动幅度、餐后血糖面积。结果:PGDM组血糖波动指标血糖标准差[(1.1±0.3)mmol/L vs.(0.9±0.2)mmol/L,P0.05]、平均血糖[(6.4±0.9)mmol/L vs.(5.8±1.0)mmol/L,P0.05]、平均血糖绝对差[(1.3±0.4)mmol/L vs.(1.1±0.4)mmol/L,P0.05]、平均血糖波动幅度[(2.5±0.4)mmol/L vs.(1.9±0.5)mmol/L,P0.05]、餐后血糖波动面积[(22.5±3.2)mmol/(L·h)vs.(19.8±3.5)mmol/(L·h),P0.05]均明显高于NC组。结论:先证GDM病史的正常糖耐量妇女血糖波动指标明显高于无GDM病史的正常糖耐量妇女。
[Abstract]:Objective: to analyze gestational diabetes mellitus of gestational diabetes mellitus. Methods: 75 g oral glucose tolerance test (OGTT) was performed in GDM women in the second affiliated Hospital of Nantong University within 1 year after delivery. 61 normal glucose tolerance women (fasting glucose 5.6 mmol/L) were selected. Glucose load 2 h 7.8 mmol / L was included in the study group, and 61 age-matched normal glucose tolerant women without history of GDM were selected as control group (NC group). All subjects were monitored continuously for 72 hours. The fluctuation parameters of blood sugar were calculated, including standard deviation of blood sugar, mean blood sugar, absolute deviation of mean blood sugar, mean fluctuation range of blood sugar, area of postprandial blood sugar. [1. 1 卤0. 3 mmol / L vs.(0.9 卤0. 2 mmol / L P 0.05, mean blood sugar. [6.4 卤0.9mmol / L vs.(5.8 卤1.0mmol / L P 0.05, mean blood glucose absolute difference (P 0.05). [1. 3 卤0. 4 mmol / L vs.(1.1 卤0. 4 mmol / L P 0.05, mean blood glucose fluctuation. [2. 5 卤0. 4 mmol / L vs.(1.9 卤0. 5 mmol / L P0.05, postprandial blood glucose fluctuating area. [22.5 卤3.2mmol-L 路hmmol-l 路hmmol-l 路hmmol-l 路hh. (19.8 卤3.5nmol / L 路h). Conclusion: the blood glucose fluctuation index of normal glucose tolerance women with history of GDM was significantly higher than that of normal glucose tolerance women without history of GDM.
【作者单位】：南通大学第二附属医院内分泌科;南通大学第二附属医院妇产科;南通市第二人民医院内分泌科;
【基金】：南通市社会事业科技创新与示范计划项目(HS2013006)
【分类号】：R714.256
【正文快照】： 妊娠期糖尿病(gestational diabetes mellitus,GDM)指妊娠期初次发生不同程度的糖耐量异常。正常妊娠时,胰岛素敏感性较孕前下降50%~60%,胰岛素糖处理能力下降约50%,同时胰岛素分泌代偿性增加2.0~2.5倍,以维持正常血糖水平;当母体胰岛不能分泌足够的胰岛素来代偿日益异常加重

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