卵巢恶性肿瘤的超声评价及研究进展

发布时间：2018-01-22 04:39

本文关键词： 卵巢肿瘤超声进展　出处：《肿瘤影像学》2016年01期 　论文类型：期刊论文

【摘要】：卵巢恶性肿瘤的死亡率高,早期诊断是提高生存率的关键。本文综述了超声影像学检查对卵巢恶性肿瘤的评价及研究进展,包括国际卵巢肿瘤分析(International Ovarian Tumor Analysis,IOTA)、超声造影对卵巢良恶性肿瘤的鉴别诊断价值、三维超声的作用,以及靶向超声微泡造影剂在卵巢癌诊疗中的研究进展等。IOTA是一项多中心、大样本持续性研究,其简易准则(simple rules,SR)和风险预测模型logistic回归模型2(logistic regression model 2,LR2)均表现出优异的诊断准确率,并且在临床经验有限的检查者(非专家)使用时,其诊断效力明显高于传统的卵巢恶性肿瘤风险指数(risk of malignancy index,RMI)模型。超声造影在附件区难以判断的囊实性包块诊断中发挥着重要作用。而三维超声对卵巢恶性肿瘤的诊断作用有限。靶向超声微泡造影剂一方面可通过靶向分子水平超声显像为卵巢癌的早期定性、定位诊断提供可能性;另一方面可携带治疗基因、药物至靶部位释放,达到提高治疗效果的作用,有可能显著提高超声对早期卵巢癌的识别能力。
[Abstract]:The mortality rate of ovarian malignant tumors is high, and early diagnosis is the key to improve the survival rate. This article reviews the evaluation and research progress of ultrasound imaging for ovarian malignant tumors. Including International Ovarian Tumor Analysis (Iota). The value of contrast-enhanced ultrasound in the differential diagnosis of benign and malignant ovarian tumors, the effect of three-dimensional ultrasound, and the research progress of targeted ultrasound microbubble contrast agent in the diagnosis and treatment of ovarian cancer, etc. IOTA is a multicenter. Large sample persistence study, its simple rules is simple. SRR) and logistic regression model (2 logistic regression model 2 LR2) showed excellent diagnostic accuracy. In addition, the diagnostic efficacy of the risk of malignancy index was significantly higher than that of the traditional risk of ovarian cancer index when the examiner (non-expert) had limited clinical experience. RMI). Model. Contrast-enhanced ultrasound plays an important role in the diagnosis of solid and cystic masses in the adnexal region. Three-dimensional ultrasound is of limited value in the diagnosis of ovarian malignant tumors. On the one hand, targeted ultrasound microbubble contrast agents can be used by targeting fraction. Sublevel ultrasound imaging is the early qualitative analysis of ovarian cancer. The possibility of localizing diagnosis; On the other hand, it can carry the therapeutic gene, drug release to the target to improve the therapeutic effect, which may significantly improve the ability of early ovarian cancer recognition by ultrasound.
【作者单位】：中国医学科学院/北京协和医院超声医学科;
【分类号】：R445.1;R737.31
【正文快照】： 卵巢恶性肿瘤是女性生殖系统三大恶性肿瘤之一,死亡率居妇科恶性肿瘤之首。尤其是卵巢癌发病较隐匿,早期多无症状,多数患者就诊时肿瘤已属中晚期。文献报道,Ⅲ期或Ⅳ期卵巢癌患者治疗后5年生存率30%,Ⅱ期约70%,而Ⅰ期可达90%以上[1]。因此,卵巢癌的早期诊断与治疗是提高卵巢

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