HPV的外周循环血测定及临床意义

发布时间：2018-01-22 06:30

本文关键词： 宫颈癌人乳头状瘤病毒检测临床意义　出处：《中国癌症杂志》2017年11期 　论文类型：期刊论文

【摘要】：高危人乳头状瘤病毒(human papillomavirus,HPV)的持续性感染是宫颈癌重要的致病因素,随着近年来宫颈癌HPV疫苗投入市场,关于HPV的检测及临床意义也成为研究热点。因为HPV致癌的特殊性,我们分析了HPV血液检测及临床应用方面存在的困难,并以血液中HPV的检出为理论基础,论证了其重要的临床意义,包括患者预后及治疗的相关最新研究进展。已有研究证实,宫颈癌患者外周循环血中HPV的持续性检出与患者的不良预后密切相关。在此基础之上,针对HPV的靶向治疗及免疫治疗在宫颈癌患者中显现出越发重要的地位。针对我们需要解决的问题,本文将着重阐述目前HPV病毒的血液学检测现状,并对其提出精准检测及治疗预后方面的展望。
[Abstract]:Persistent infection of high risk human papillomavirus (HPV) is an important risk factor for cervical cancer. With the introduction of cervical cancer HPV vaccine into the market in recent years, the detection and clinical significance of HPV has become a hot research topic, because of the particularity of HPV carcinogenesis. We analyzed the difficulties in blood detection and clinical application of HPV, and demonstrated its important clinical significance based on the detection of HPV in blood. It has been confirmed that the persistent detection of HPV in peripheral blood of patients with cervical cancer is closely related to the poor prognosis of patients. Targeted therapy and immunotherapy of HPV have become more and more important in cervical cancer patients. In view of the problems we need to solve, this paper will focus on the current status of HPV virus hematological detection. At the same time, the prospect of accurate detection and treatment and prognosis was put forward.
【作者单位】：复旦大学附属肿瘤医院妇瘤科复旦大学上海医学院肿瘤学系;
【分类号】：R737.33
【正文快照】： 宫颈癌是女性中第二常见的恶性肿瘤,我指南中更新了HPV的起始筛查年龄,从30岁降低国宫颈癌的发病率从2000年的4.0/10万到2011年到了25岁[5]。作为宫颈癌一、二级预防的有效的9.5/10万呈成倍上升趋势[1],超过98%的宫手段,人群中HPV的筛查及其疫苗的广泛接种,颈癌[2]组织中能分

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