多囊卵巢综合征患者合并代谢综合征的患病率和预测指标

发布时间：2018-01-23 00:01

本文关键词： 多囊卵巢综合征代谢综合征患病率预测指标　出处：《首都医科大学学报》2015年04期 　论文类型：期刊论文

【摘要】：目的探讨多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者代谢综合征(metabolic syndrome,MS)及其各组分的发病情况,评估MS各组分对预测PCOS患者合并MS的预测能力。方法选取2013年12月至2014年7月就诊于首都医科大学附属北京妇产医院内分泌科被确诊为多囊卵巢综合征患者180例,所有患者均收集人体测量学指标、基础内分泌指标和血糖血脂等生物化学指标,评估PCOS患者MS及其各组分的发病情况,筛选对PCOS患者发生MS高风险的预测指标。结果 1 180例PCOS患者MS的患病率为43.89%;2不同年龄段的患病率分别为17~24岁32.14%、25~29岁39.53%、30~34岁50%、35~39岁80%;正常体质量、超质量、肥胖、重度肥胖的患病率非别为10.00%、51.16%、69.57%、85.71%;3合并有MS的PCOS患者的年龄和体质量指数均高于非MS的PCOS患者(29.16±3.85 vs 27.47±3.81,P=0.004;31.44±4.89 vs 24.29±4.87,P=0.000),两组患者的血总睾酮浓度差异无统计学意义(P0.05);4 PCOS患者发生MS最好的预测指标是高密度脂蛋白胆固醇1.29 mmol/L(敏感度为91.14%,特异度为88.12%)。结论 PCOS患者是发生代谢综合征的高风险人群,年龄和肥胖情况是决定不同人群代谢综合征患病率的关键因素。通过高密度脂蛋白胆固醇水平可以较好的评估PCOS患者发生代谢综合征的风险。
[Abstract]:Objective to study the polycystic ovarian syndrome of polycystic ovary syndrome (PCOS). The incidence of metabolic syndrome (MSM) and its components in patients with PCOS. To evaluate the predictive ability of MS components in predicting PCOS patients with MS. Methods selected from December 2013 to July 2014, the department of Endocrinology and Endocrinology, affiliated Beijing Maternity Hospital of Capital Medical University, was diagnosed. 180 patients with polycystic ovary syndrome. All patients collected anthropometric indicators, basic endocrine indicators, blood glucose and blood lipids and other biochemical indicators to assess the incidence of MS and its components in patients with PCOS. Results the prevalence rate of MS in 1,180 PCOS patients was 43.89. (2) the prevalence rates of different age groups were 1724 years old 32.14 years old, 2529 years old 39.53 years old and 3034 years old 50 years old, and 35 years old and 39 years old 80 years old respectively; The prevalence of normal body mass, excess weight, obesity and severe obesity was not different from that of 10.00 and 51.16%, 69.57% and 85.71%, respectively. 3 the age and body mass index of PCOS patients with MS were higher than those of PCOS patients without MS (29.16 卤3.85 vs 27.47 卤3.81). 31.44 卤4.89 vs 24.29 卤4.87 P 0.000, there was no significant difference in serum total testosterone concentration between the two groups (P 0.05). 4 the best predictor of MS in PCOS patients was high density lipoprotein cholesterol (HDL-C) 1.29 mmol / L (sensitivity = 91.14%). Conclusion PCOS patients are at high risk of metabolic syndrome. Age and obesity are the key factors to determine the prevalence of metabolic syndrome in different population. High density lipoprotein cholesterol level can be used to evaluate the risk of metabolic syndrome in patients with PCOS.
【作者单位】：首都医科大学附属北京妇产医院内分泌科;德国图宾根大学妇产医院内分泌与绝经中心;
【基金】：国家外国专家局2015年度北京市引进国外技术、管理人才项目(GDJ20151100013) 北京市卫生系统高层次卫生技术人才(2014-2-016) 首都医科大学附属北京妇产医院,北京妇幼保健院学科带头人项目(2013-1)~~
【分类号】：R711.75;R589
【正文快照】： (1.首都医科大学附属北京妇产医院内分泌科,北京100026;2.德国图宾根大学妇产医院内分泌与绝经中心,图宾根D-72076,德国)多囊卵巢综合征(polycystic ovary syndrome,P-COS)是一种育龄期女性最常见的内分泌紊乱疾病,根据美国国立卫生研究院(National Institutes ofHealth,NIH)

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