宫颈癌患者脉管内癌栓浸润与其他临床病理因素的相关性分析

发布时间：2018-01-24 03:46

本文关键词： 宫颈肿瘤癌血管淋巴管栓塞和血栓形成肿瘤转移　出处：《国际妇产科学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的:分析宫颈脉管内癌栓浸润(lymph-vascular space invasion,LVSI)与宫颈癌其他临床病理因素的关系,为指导宫颈癌治疗提供依据。方法:回顾性分析2003年4月—2013年5月上海市第一妇婴保健院收治的462例宫颈癌患者的临床及病理资料,其中LVSI阳性者185例(40%),阴性者277例(60%),对LVSI与肿瘤分期、淋巴结转移及其他临床、病理因素的关系进行相关性分析。结果:单因素分析显示宫颈癌患者LVSI的发生与肿瘤分期、肿瘤大小、浸润深度、淋巴结转移、是否术前经过新辅助治疗有关,而与采用何种新辅助治疗方法无关。LVSI与宫颈癌的其他5项高危因素,即组织病理学类型、间质浸润深度、肿瘤体积、宫旁浸润、淋巴结转移有关;且合并的高危因素越多,LVSI的发生率越高。结论:LVSI与其他病理高危因素密切相关,可能更早地提示淋巴结转移等其他高危因素的潜在风险,对指导宫颈癌的治疗意义重大。
[Abstract]:Objective: to analyze the relationship between lymph-vascular space invasionus (LVSI) and other clinicopathological factors of cervical carcinoma. Methods: from April 2003 to May 2013, the clinical and pathological data of 462 patients with cervical cancer were analyzed retrospectively. Among them, 185 cases were positive for LVSI and 60 cases were negative for LVSI, lymph node metastasis and other clinical manifestations. Results: univariate analysis showed that LVSI was associated with tumor stage, tumor size, depth of invasion, lymph node metastasis. Whether preoperative neo-adjuvant therapy is relevant, but not with the new adjuvant therapy. LVSI and the other five high risk factors of cervical cancer, namely histopathological type, depth of interstitial infiltration, tumor volume. Para-uterine invasion, lymph node metastasis; The more risk factors associated with LVSI, the higher the incidence of LVSI. Conclusion the ratio of LVSI to other pathological high risk factors is closely related, which may indicate the potential risk of other high risk factors such as lymph node metastasis earlier. It is of great significance to guide the treatment of cervical cancer.
【作者单位】：上海市第一妇婴保健院;
【基金】：国家自然科学基金(81372787) 2013年度上海市卫生和计划生育委员会委级科研项目(20134033) 浦东新区卫生局卫生科技项目(PW2010D-5)
【分类号】：R737.33
【正文快照】： (J Int Obstet Gynecol,2016,43:87-91)目前,宫颈癌仍是妇科最常见的恶性肿瘤之一。据统计,全球范围内每年大约有50万新发的宫颈癌病例,其中85%的病例发生在发展中国家,中国每年大约新增病例13.15万例[1-2]。评价子宫颈癌预后的相关因素成为目前研究的焦点,其中研究最多的六大

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